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Stroke, Vol 16, 595-602, Copyright © 1985 by American Heart Association


ARTICLES

Subarachnoid haemorrhage in the rat: angiography and fluorescence microscopy of the major cerebral arteries

TJ Delgado, J Brismar and NA Svendgaard

A subarachnoid haemorrhage (SAH) in the rat was produced by the injection of blood via a previously implanted catheter connected to the cisterna magna. Repeated angiographical examinations of the vertebro- basilar arteries revealed a biphasic vasospasm with a maximal acute spasm at ten minutes and a maximal late spasm at two days after cisternal blood injection. Fluorescence microscopical examination of the major cerebral arteries at day two after the SAH revealed a reduction in the fluorescence intensity and in the number of histochemically visible sympathetic nerve terminals.


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