This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shah, A. B. Articles by Coull, B. M. Search for Related Content PubMed PubMed Citation Articles by Shah, A. B. Articles by Coull, B. M.

Stroke, Vol 16, 643-647, Copyright © 1985 by American Heart Association

ARTICLES

Enhanced in vivo platelet activation in subtypes of ischemic stroke

AB Shah, N Beamer and BM Coull

It remains uncertain whether platelet activation in ischemic stroke is contributory or secondary to brain ischemia. The efficacy of aspirin (ASA) in stroke prevention suggests that platelet activation contributes to the occurrence of stroke. On the other hand, platelet activation may be simply a generalized consequence of cerebral ischemic damage. To examine this issue, plasma levels of the platelet specific proteins beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) were measured in fifty-eight patients with various defined types of acute ischemic strokes. beta-TG was a broader indicator of platelet activation than PF4. Compared with an age-matched control group, thromboembolic and cardioembolic stroke patients had significantly elevated beta-TG levels (p less than 0.001). Also, beta-TG levels in these stroke categories were significantly higher in samples drawn within the first week after the event than in those drawn later (p less than 0.001). In contrast, beta-TG levels in lacunar stroke patients and in most TIA patients were normal. beta-TG levels did not correlate with the volume of cerebral infarction as measured by planimetry from CT scans. Moreover, beta-TG levels in patients on chronic ASA therapy at the time of stroke did not differ from those in patients of the same diagnostic categories not taking aspirin. These data indicate that platelet activation may be important in some, but not all, subtypes of ischemic stroke and that platelet activation can occur in stroke even though the platelet cyclooxygenase pathway is suppressed.

This article has been cited by other articles:

				H. -K. Yip, C. -H. Lu, C. -H. Yang, H. -W. Chang, W. -C. Hung, C. -I. Cheng, S. -M. Chen, and C. -J. Wu Levels and value of platelet activity in patients with severe internal carotid artery stenosis Neurology, March 28, 2006; 66(6): 804 - 808. [Abstract] [Full Text] [PDF]

				M. Karakantza, A. Maniatis, C. I. Metallinos, T. Papapetropoulos, C. Paschalis, A. J. Grau, L. Marquardt, and A. Ruf In Vivo Platelet Activation in Ischemic Stroke Patients * Response Stroke, October 1, 2003; 34 (10): e174 - e175. [Full Text] [PDF]

				T. Abumiya, R. Fitridge, C. Mazur, B. R. Copeland, J. A. Koziol, J. F. Tschopp, M. D. Pierschbacher, G. J. del Zoppo, and P. D. Hurn Integrin {alpha}IIb{beta}3 Inhibitor Preserves Microvascular Patency in Experimental Acute Focal Cerebral Ischemia Editorial Comment Stroke, June 1, 2000; 31(6): 1402 - 1410. [Abstract] [Full Text] [PDF]

				W. M. Feinberg, L. A. Pearce, R. G. Hart, M. Cushman, E. S. Cornell, G. Y.H. Lip, and E. G. Bovill Markers of Thrombin and Platelet Activity in Patients With Atrial Fibrillation : Correlation With Stroke Among 1531 Participants in the Stroke Prevention in Atrial Fibrillation III Study Stroke, December 1, 1999; 30(12): 2547 - 2553. [Abstract] [Full Text] [PDF]

				A. M. Carter, A. J. Catto, J. M. Bamford, and P. J. Grant Association of the Platelet Glycoprotein IIb HPA-3 Polymorphism With Survival After Acute Ischemic Stroke Stroke, December 1, 1999; 30(12): 2606 - 2611. [Abstract] [Full Text] [PDF]

				N. M Smith, R. Pathansali, and P. M. Bath Platelets and stroke Vascular Medicine, August 1, 1999; 4(3): 165 - 172. [Abstract] [PDF]

				A. M. Carter, A. J. Catto, J. M. Bamford, and P. J. Grant Platelet GP IIIa PlA and GP Ib Variable Number Tandem Repeat Polymorphisms and Markers of Platelet Activation in Acute Stroke Arterioscler. Thromb. Vasc. Biol., July 1, 1998; 18(7): 1124 - 1131. [Abstract] [Full Text] [PDF]

				M. T. Littleton-Kearney, P. D. Hurn, T. S. Kickler, and R. J. Traystman Incomplete global cerebral ischemia alters platelet biology in neonatal and adult sheep Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1293 - H1300. [Abstract] [Full Text] [PDF]

				V. L. Serebruany, P. A. Gurbel, A. R. Shustov, M. R. Dalesandro, C. I. Gumbs, L. B. Grabletz, R. D. Bahr, E. M. Ohman, and E. J. Topol Depressed Platelet Status in an Elderly Patient With Hemorrhagic Stroke After Thrombolysis for Acute Myocardial Infarction Stroke, January 1, 1998; 29(1): 235 - 238. [Abstract] [Full Text] [PDF]

				C.-P. Lau, H.-F. Tse, and G. Cheng Effects of atrioventricular asynchrony on platelet activation: implication of thromboembolism in paced patients Heart, October 1, 1997; 78(4): 358 - 363. [Abstract] [Full Text] [PDF]

				W. M. Feinberg, L. P. Erickson, D. Bruck, and J. Kittelson Hemostatic Markers in Acute Ischemic Stroke: Association With Stroke Type, Severity, and Outcome Stroke, August 1, 1996; 27(8): 1296 - 1300. [Abstract] [Full Text]

				T. Nagao, M. Hamamoto, A. Kanda, T. Tsuganesawa, M. Ueda, K. Kobayashi, T. Miyazaki, and A. Terashi Platelet Activation Is Not Involved in Acceleration of the Coagulation System in Acute Cardioembolic Stroke With Nonvalvular Atrial Fibrillation Stroke, August 1, 1995; 26(8): 1365 - 1368. [Abstract] [Full Text]

				T. O'Malley, P. Langhorne, R.A. Elton, and C. Stewart Platelet Size in Stroke Patients Stroke, June 1, 1995; 26(6): 995 - 999. [Abstract] [Full Text]

				T. Iwamoto, H. Kubo, and M. Takasaki Platelet Activation in the Cerebral Circulation in Different Subtypes of Ischemic Stroke and Binswanger's Disease Stroke, January 1, 1995; 26(1): 52 - 56. [Abstract] [Full Text]