This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Postiglione, A. Articles by Mancini, M. Search for Related Content PubMed PubMed Citation Articles by Postiglione, A. Articles by Mancini, M.

Stroke, Vol 16, 658-661, Copyright © 1985 by American Heart Association

ARTICLES

Carotid atherosclerosis in familial hypercholesterolemia

A Postiglione, P Rubba, B De Simone, L Patti, U Cicerano and M Mancini

Common and internal carotids have been studied by noninvasive method (echo-Doppler) in 30 normotensive patients with familial hypercholesterolemia (FH). Vascular lesions were detected in 14 patients (46%), who presented one or more lesions of different degree (between 1-15% and 16-49%). In one case, only one carotid had stenosis greater than 50%. Severity and number of stenosis were related to age and levels of hypercholesterolemia. FH patients with carotid lesions showed a significantly higher LDL-cholesterol (p less than 0.01) and plasma apolipoprotein B (p less than 0.001) concentrations and a significantly lower HDL-cholesterol (p less than 0.05) and plasma apolipoprotein A (p less than 0.001) levels as compared to those with normal echo-Doppler findings. These data indicate that investigation of arterial districts other than coronaries are useful in quantitative evaluation of atherosclerotic involvement.

This article has been cited by other articles:

				F. Orio Jr., S. Palomba, T. Cascella, B. De Simone, S. Di Biase, T. Russo, D. Labella, F. Zullo, G. Lombardi, and A. Colao Early Impairment of Endothelial Structure and Function in Young Normal-Weight Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4588 - 4593. [Abstract] [Full Text] [PDF]

				C. M. Hutter, M. A. Austin, and S. E. Humphries Familial Hypercholesterolemia, Peripheral Arterial Disease, and Stroke: A HuGE Minireview Am. J. Epidemiol., September 1, 2004; 160(5): 430 - 435. [Abstract] [Full Text] [PDF]

				R.R. Huxley, M.H. Hawkins, S.E. Humphries, F. Karpe, H.A.W. Neil, and J. F. Meschia Risk of Fatal Stroke in Patients With Treated Familial Hypercholesterolemia: A Prospective Registry Study * Editorial Comment Stroke, January 1, 2003; 34(1): 22 - 25. [Abstract] [Full Text] [PDF]

				H. J Milionis, A. F Winder, and D. P Mikhailidis Lipoprotein (a) and stroke J. Clin. Pathol., July 1, 2000; 53(7): 487 - 496. [Abstract] [Full Text] [PDF]

				L. Cattin, M. Fisicaro, M. Tonizzo, M. Valenti, G.M. Danek, M. Fonda, P.G. Da Col, S. Casagrande, E. Pincetti, M. Bovenzi, et al. Polymorphism of the Apolipoprotein E Gene and Early Carotid Atherosclerosis Defined by Ultrasonography in Asymptomatic Adults Arterioscler. Thromb. Vasc. Biol., January 1, 1997; 17(1): 91 - 94. [Abstract] [Full Text]

				D. B. White, J. R. Schneider, K. N. Hoffman, G. P. Size, R. W. Coats II, M. Laubach, E. J. Erickson, J. A. Caprini, and J. F. Golan Association Between Carotid Artery Bifurcation Disease and Risk Factors for Atherosclerosis Vascular and Endovascular Surgery, November 1, 1996; 30(6): 495 - 503. [Abstract] [PDF]

				S. Tonstad, O. Joakimsen, E. Stensland-Bugge, T. P. Leren, L. Ose, D. Russell, and K. H. Bonaa Risk Factors Related to Carotid Intima-Media Thickness and Plaque in Children With Familial Hypercholesterolemia and Control Subjects Arterioscler. Thromb. Vasc. Biol., August 1, 1996; 16(8): 984 - 991. [Abstract] [Full Text]