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Stroke, Vol 17, 728-730, Copyright © 1986 by American Heart Association

ARTICLES

The effect of intravenous lidoflazine on serotonin-induced cerebral vascular contraction--an in vivo study

RH Rosenwasser, RF Tuma and WA Buchheit

Lidoflazine, a piperazine derivative with known selectivity for vascular smooth muscle, was evaluated as a possible agent for prophylaxis of cerebral vascular contraction induced by subarachnoid perfusion with serotonin. The animals treated with serotonin (5 X 10(- 6) M), had a 60% reduction in the diameter of basilar artery but when pretreated with Lidoflazine (1 mg/kg) intravenously, only had a 20% reduction in diameter (p less than 0.01). Lidoflazine, when administered intravenously at a slow rate will not adversely lower systemic blood pressure and can prevent the contraction of cerebral vessels when the stimulus for contraction is in the subarachnoid space.