This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wise, R. Articles by Jones, T. Search for Related Content PubMed PubMed Citation Articles by Wise, R. Articles by Jones, T.

Stroke, Vol 17, 853-861, Copyright © 1986 by American Heart Association

ARTICLES

No evidence for transhemispheric diaschisis after human cerebral infarction

R Wise, J Gibbs, R Frackowiak, J Marshall and T Jones

Forty-four studies of regional cerebral blood flow (rCBF), fractional oxygen extraction (rOER) and oxygen consumption (rCMRO2) were made on twenty-five patients with recent internal carotid artery territory infarcts. The purpose was to study flow-metabolism relationships in the contralateral hemispheres, and to investigate whether contralateral rCMRO2 was depressed as a result of the recent infarcts. Two groups of controls were included for comparison--seventeen normal volunteers, and ten patients with proven extracranial cerebrovascular disease but without evidence of cerebral infarction. The results demonstrated that: contralateral hemispheric rCMRO2 was less variable than regional oxygen availability (the product of rCBF and arterial oxygen content). This was due, in part, to the effect of individual variations in PaCO2 on rCBF, but other uncontrolled factors, such as intracranial pressure, may have had influences. As a result, rCMRO2 did not correlate with rCBF; mean rCMRO2 in the contralateral hemispheres was 12% lower than normal (a significant difference), but was not different from the value found in patients with extracranial vascular disease in whom there was no evidence of infarction or ischemia; contralateral rCMRO2 did not correlate with the size of the infarct in the opposite hemisphere. It is concluded that rCMRO2 cannot be inferred from rCBF measurements in uncontrolled human studies (as frequently done in the past), and that depression of contralateral rCMRO2 may have preceded infarction in the opposite hemisphere, a consequence of the previous influences of diseases that predispose to stroke.

This article has been cited by other articles:

				K. Yamada, R. G. Gonzalez, L. Ostergaard, S. Komili, R. M. Weisskoff, B. R. Rosen, W. J. Koroshetz, T. Nishimura, and A. G. Sorensen Iron-Induced Susceptibility Effect at the Globus Pallidus Causes Underestimation of Flow and Volume on Dynamic Susceptibility Contrast-Enhanced MR Perfusion Images AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 1022 - 1029. [Abstract] [Full Text] [PDF]

				S. Iglesias, G. Marchal, P. Rioux, V. Beaudouin, J.L. Hauttement, V. de la Sayette, F. Le Doze, J.M. Derlon, F. Viader, and J.C. Baron Do Changes in Oxygen Metabolism in the Unaffected Cerebral Hemisphere Underlie Early Neurological Recovery After Stroke?: A Positron Emission Tomography Study Stroke, July 1, 1996; 27(7): 1192 - 1199. [Abstract] [Full Text]

				I. Buchkremer-Ratzmann, M. August, G. Hagemann, and O. W. Witte Electrophysiological Transcortical Diaschisis After Cortical Photothrombosis in Rat Brain Stroke, June 1, 1996; 27(6): 1105 - 1111. [Abstract] [Full Text]

				J. V. Bowler, J. P. H. Wade, B. E. Jones, K. Nijran, R. F. Jewkes, R. Cuming, and T. J. Steiner Contribution of Diaschisis to the Clinical Deficit in Human Cerebral Infarction Stroke, June 1, 1995; 26(6): 1000 - 1006. [Abstract] [Full Text]

				M. Rango, L. Candelise, D. Perani, C. Messa, G. Scarlato, N. Canal, M. Franceschi, and F. Fazio Cortical Pathophysiology and Clinical Neurologic Abnormalities in Acute Cerebral Ischemia: A Serial Study With Single Photon Emission Computed Tomography Arch Neurol, December 1, 1989; 46(12): 1318 - 1322. [Abstract] [PDF]