Stroke, Vol 18, 990-996, Copyright © 1987 by American Heart Association
JR Crouse, JF Toole, WM McKinney, MB Dignan, G Howard, FR Kahl, MR McMahan and GH Harpold
We related risk factors, cardiovascular symptoms, and coronary status to
the extent of extracranial carotid atherosclerosis as measured by B- mode
ultrasonography in 376 volunteers hospitalized for elective coronary
angiography. In a first analysis, we correlated risk factors and
cardiovascular symptoms with carotid atherosclerosis. Univariate analysis
showed that relations between many continuous risk factors and carotid
atherosclerosis were graded and consistent for men and women. Multivariate
analysis identified 6 significant variables (age, hypertension, pack-years
smoked, and inversely, plasma concentrations of high density lipoprotein
cholesterol and uric acid, and Framingham Type A score) that together
accounted for 35% of the variability in extent of carotid atherosclerosis.
In a second multivariate analysis, addition of coronary status (presence or
absence of coronary stenosis as evaluated by coronary angiography) to the
roster of candidate independent variables produced a new equation that
accounted for an additional 5% of the variability in carotid
atherosclerosis extent. Although much of the variability in extent of
carotid atherosclerosis remains unexplained, these data define an
association between coronary and carotid atherosclerosis that depends
partly on shared exposure of both arteries to the same risk factors. They
are also consistent with the concept that as yet undiscovered risk factors
and/or genetic (e.g., arterial wall) factors common to both arterial beds
also contribute to the relation between coronary and carotid
atherosclerosis in human beings.
ARTICLES
Risk factors for extracranial carotid artery atherosclerosis
Department of Medicine, Wake Forest University Medical Center, Bowman Gray School of Medicine, Winston-Salem, N.C. 27103.
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