Stroke, Vol 19, 863-869, Copyright © 1988 by American Heart Association
JM Hallenbeck, AJ Dutka, PM Kochanek, A Siren, GH Pezeshkpour and G Feuerstein
Stroke risk factors such as hypertension, diabetes, advanced age, and
genetic predisposition to stroke were demonstrated to prepare rat brainstem
tissues for a modified local Shwartzman reaction. A single intracisternal
injection of endotoxin provoked the reaction, and affected rats manifested
neurologic deficits accompanied by pathologic lesions. Brainstem infarcts
developed in only a small proportion of rats without recognized risk
factors after intracisternal injection of endotoxin. Thus, stroke risk
factors, which are ordinarily regarded as operating through acceleration of
atherosclerosis, may predispose to brain ischemia by local effects on brain
microcirculation such as those thought to underlie preparation of a tissue
for the local Shwartzman reaction.
ARTICLES
Stroke risk factors prepare rat brainstem tissues for modified local Shwartzman reaction
Neurology Department, Naval Hospital, Bethesda, Maryland 20814-5055.
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