This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Faraci, F. M. Articles by Heistad, D. D. Search for Related Content PubMed PubMed Citation Articles by Faraci, F. M. Articles by Heistad, D. D. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

Stroke, Vol 20, 242-247, Copyright © 1989 by American Heart Association

ARTICLES

Atherosclerosis potentiates constrictor responses of cerebral and ocular blood vessels to thromboxane in monkeys

FM Faraci, JK Williams, KR Breese, ML Armstrong and DD Heistad
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.

The goal of our study was to examine the effects of infusion of serotonin and the thromboxane A2 analogue U46619 into one carotid artery to stimulate their release from platelets during aggregation. We measured blood flow to the brain and eye using microspheres and cerebral microvascular pressure in the pial arteries of normal and atherosclerotic cynomolgus monkeys. Unilateral intracarotid infusion of 10-30 micrograms/min serotonin did not affect cerebral blood flow in normal or atherosclerotic monkeys; serotonin did not alter blood flow to the eye in normal monkeys but decreased flow to the retina and choroid in atherosclerotic monkeys by 39 +/- 11% and 44 +/- 10% (mean +/- SEM), respectively. Infusion of 30 ng/min U46619 did not alter cerebral blood flow but increased the pressure gradient from the aorta to the pial artery, which is an index of large-artery resistance, in atherosclerotic monkeys. U46619 had no effect on blood flow to the eye in normal monkeys but decreased blood flow to the retina and choroid by 71 +/- 14% and 53 +/- 13%, respectively, in atherosclerotic monkeys. Thus, atherosclerosis potentiates the constrictor responses of large cerebral arteries to thromboxane and the responses of blood vessels of the eye to thromboxane and serotonin.

This article has been cited by other articles:

				K. Niwa, V. A. Porter, K. Kazama, D. Cornfield, G. A. Carlson, and C. Iadecola Abeta -peptides enhance vasoconstriction in cerebral circulation Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2417 - H2424. [Abstract] [Full Text] [PDF]

				M. Nakajima, I. Date, K. Takahashi, Y. Ninomiya, S. Asari, and T. Ohmoto Effects of Aging on Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbits Stroke, March 1, 2001; 32(3): 620 - 628. [Abstract] [Full Text] [PDF]

				F. M. FARACI and D. D. HEISTAD Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels Physiol Rev, January 1, 1998; 78(1): 53 - 97. [Abstract] [Full Text] [PDF]

				J. Winterkorn, M. J. Kupersmith, J. D. Wirtschafter, and S. Forman Treatment of Vasospastic Amaurosis Fugax with Calcium-Channel Blockers N. Engl. J. Med., August 5, 1993; 329(6): 396 - 398. [Full Text]