This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Juvela, S. Articles by Hillbom, M. Search for Related Content PubMed PubMed Citation Articles by Juvela, S. Articles by Hillbom, M.

Stroke, Vol 21, 566-571, Copyright © 1990 by American Heart Association

ARTICLES

Platelet thromboxane release after subarachnoid hemorrhage and surgery

S Juvela, M Kaste and M Hillbom
Departments of Neurosurgery, Helsinki University Central Hospital, Finland.

We studied adenosine diphosphate-induced platelet aggregation and the associated release of thromboxane B2 in platelet-rich plasma from 88 patients with subarachnoid hemorrhage and 26 healthy controls. During the first 3 days after subarachnoid hemorrhage, the patients showed significantly decreased (p less than 0.05) platelet aggregability and thromboxane release relative to the controls, but these effects disappeared in a few days. Platelet count increased for 3 weeks after subarachnoid hemorrhage. Surgery in 67 patients was followed by significant increases in platelet aggregability (p less than 0.05) and thromboxane release (p less than 0.001). Greatest thromboxane release was found in the eight patients showing delayed (postoperative) ischemic deterioration with a permanent neurologic deficit. Although platelet hyperaggregability and increased thromboxane release were particularly prominent in these eight patients, the role of these hematologic parameters in the pathogenesis of delayed ischemic deterioration remains unclear.

This article has been cited by other articles:

				Y. Fujii, S. Takeuchi, A. Harada, H. Abe, O. Sasaki, and R. Tanaka Hemostatic Activation in Spontaneous Intracerebral Hemorrhage Stroke, April 1, 2001; 32(4): 883 - 890. [Abstract] [Full Text] [PDF]

				J. van Gijn and G. J. E. Rinkel Subarachnoid haemorrhage: diagnosis, causes and management Brain, February 1, 2001; 124(2): 249 - 278. [Abstract] [Full Text] [PDF]

				J. W. Hop, G. J. E. Rinkel, A. Algra, J. W. B. van der Sprenkel, and J. van Gijn Randomized pilot trial of postoperative aspirin in subarachnoid hemorrhage Neurology, February 22, 2000; 54(4): 872 - 878. [Abstract] [Full Text] [PDF]

				J. W. Hop, G. J. E. Rinkel, A. Algra, and J. van Gijn Initial Loss of Consciousness and Risk of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage Stroke, November 1, 1999; 30(11): 2268 - 2271. [Abstract] [Full Text] [PDF]