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Stroke, Vol 21, 707-714, Copyright © 1990 by American Heart Association
JP Whisnant, D Homer, TJ Ingall, HL Baker Jr, WM O'Fallon and DO Wievers
The effect of cigarette smoking on extracranial carotid atherosclerosis was
studies by obtaining cigarette smoking histories and information on other
potential risk factors from consecutive patients undergoing carotid
arteriography. At least on extracranial carotid artery was visualized in
752 patients in whom the extent of carotid atherosclerosis was assessed.
The total years of cigarette smoking was the most significant independent
predictor of the presence of severe carotid atherosclerosis. Other
independent predictors, in order of significance, were age, hypertension,
diabetes mellitus, male sex, and current systolic blood pressure. By age 60
years, the risk of having severe carotid atherosclerosis for a person who
had smoked for 40 years was approximately 3.5 times that for a never
smoker. The major benefit of smoking cessation is in limiting the
accumulation of smoking years.
ARTICLES
Duration of cigarette smoking is the strongest predictor of severe extracranial carotid artery atherosclerosis
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905.
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