Stroke, Vol 22, 162-168, Copyright © 1991 by American Heart Association
BM Coull, N Beamer, P de Garmo, G Sexton, F Nordt, R Knox and GV Seaman
The origin and significance of blood hyperviscosity in subjects with acute
stroke has been controversial. It has been argued that viscous
abnormalities simply reflect either elevated hematocrit or an acute- phase
response to the stroke itself. To address these issues, we measured the
factors that determine blood viscosity in a cross- sectional study of 430
subjects, including 135 with acute stroke, 89 with acute transient ischemic
attacks of the brain, 115 with recognized risk factors for stroke, and 91
healthy controls. The at-risk group was balanced with the acute stroke
group for types of risk factors and medication usage, and all four groups
were balanced for age. The viscosity of whole blood at low rates of shear
and the plasma viscosity were significantly elevated in both groups with
cerebrovascular symptoms and in the at-risk group compared with the healthy
controls. The severity of hyperviscosity was stroke group greater than
transient ischemic attack group greater than at-risk group greater than
healthy controls. Increased viscosity of whole blood was associated with an
elevated plasma fibrinogen concentration and with a decreased
albumin/globulin ratio. This study provides evidence that blood
hyperviscosity is present not only in subjects with acute brain infarction,
but also in those with risk factors for stroke, and that these
abnormalities are, to a considerable degree, chronic.
ARTICLES
Chronic blood hyperviscosity in subjects with acute stroke, transient ischemic attack, and risk factors for stroke
Oregon Health Sciences University, Portland.
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