Stroke, Vol 22, 378-383, Copyright © 1991 by American Heart Association
S Yoshimoto, Y Ishizaki, T Sasaki and S Murota
We have previously reported the production of endothelin, a potent
vasoconstrictor peptide, by porcine cerebral microvessel endothelia and
suggested its important role in the regulation of local blood flow within
the brain. In our present study, radioimmunoassay with anti- porcine
endothelin antiserum revealed that endothelin, produced by cerebral
microvessel endothelia grown on a filter, is released mainly to the
basement membrane side, not the vascular lumen side. This finding suggests
that endothelin constricts arterioles locally where it is produced by
endothelia. We also found that cerebral microvessel endothelia produce less
endothelin under low oxygen pressure and more endothelin under low carbon
dioxide pressure. Our results suggest that endothelin has a role in the
regulation of cerebral blood flow in response to oxygen and carbon dioxide
pressure.
ARTICLES
Effect of carbon dioxide and oxygen on endothelin production by cultured porcine cerebral endothelial cells
Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan.
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