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Stroke, Vol 22, 442-446, Copyright © 1991 by American Heart Association
A Furuta, N Ishii, Y Nishihara and A Horie
We examined sclerotic changes of the medullary arteries in 110
nonneuropsychiatric patients ranging in age from the second to the ninth
decades, in 20 patients with subcortical arteriosclerotic encephalopathy
(Binswanger's disease), and in 20 patients with dementia of the Alzheimer
type. The principal sclerotic change was fibrohyaline thickening of the
wall, which began to appear during the late fourth decade, increased in
incidence gradually with age, and was most severe in patients with
subcortical arteriosclerotic encephalopathy. Morphometry showed that the
sclerotic changes of the medullary arteries were most prominent in the
frontal lobe, followed by the parietal, occipital, and temporal lobes, in
both the nonneuropsychiatric and demented groups. The sclerotic rate in the
frontal lobe of patients with dementia of the Alzheimer type was slightly
higher than that in the nonneuropsychiatric patients (p less than 0.05) but
far less than that in the patients with subcortical arteriosclerotic
encephalopathy (p less than 0.001). The sclerotic rate correlated well with
the degree of ischemic white matter changes as well as with blood pressure.
ARTICLES
Medullary arteries in aging and dementia
Department of Pathology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu-shi, Japan.
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