Stroke, Vol 22, 971-982, Copyright © 1991 by American Heart Association
RL Macdonald and BK Weir
We believe that current experimental and clinical evidence can be most
satisfactorily interpreted by assuming that oxyhemoglobin is the cause of
cerebral vasospasm that follows subarachnoid hemorrhage. We review the
pathogenetic mechanisms by which oxyhemoglobin affects cerebral arteries.
The relative importance of each of these mechanisms in the genesis of
vasospasm, the biochemical pathways of oxyhemoglobin-induced smooth muscle
contraction, and the intracellular actions of oxyhemoglobin on smooth
muscle and on other cells in arteries are still not definitely established.
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A review of hemoglobin and the pathogenesis of cerebral vasospasm
Division of Neurosurgery, University of Alberta, Edmonton, Canada.
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M. A. Yakubu and C. W. Leffler Regulation of ET-1 biosynthesis in cerebral microvascular endothelial cells by vasoactive agents and PKC Am J Physiol Cell Physiol, February 1, 1999; 276(2): C300 - C305. [Abstract] [Full Text] [PDF]
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H. Onoue, M. Tsutsui, L. Smith, A. Stelter, T. O'Brien, Z. S. Katusic, and F. M. Faraci Expression and Function of Recombinant Endothelial Nitric Oxide Synthase Gene in Canine Basilar Artery After Experimental Subarachnoid Hemorrhage • Editorial Comment Stroke, September 1, 1998; 29(9): 1959 - 1966. [Abstract] [Full Text] [PDF]
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J. F. Megyesi, J. M. Findlay, B. Vollrath, D. A. Cook, and M. H. Chen In Vivo Angioplasty Prevents the Development of Vasospasm in Canine Carotid Arteries : Pharmacological and Morphological Analyses Stroke, June 1, 1997; 28(6): 1216 - 1224. [Abstract] [Full Text]
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M. G. Muhonen, H. Ooboshi, M. J. Welsh, B. L. Davidson, and D. D. Heistad Gene Transfer to Cerebral Blood Vessels After Subarachnoid Hemorrhage Stroke, April 1, 1997; 28(4): 822 - 829. [Abstract] [Full Text]
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A. F.Y. Chen, T. O'Brien, M. Tsutsui, H. Kinoshita, V. J. Pompili, T. B. Crotty, D. J. Spector, and Z. S. Katusic Expression and Function of Recombinant Endothelial Nitric Oxide Synthase Gene in Canine Basilar Artery Circ. Res., March 1, 1997; 80(3): 327 - 335. [Abstract] [Full Text]
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K. Nakao, H. Murata, K. Kanamaru, S. Waga, and Z. S. Katusic Effects of Nitroglycerin on Vasospasm and Cyclic Nucleotides in a Primate Model of Subarachnoid Hemorrhage Stroke, October 1, 1996; 27(10): 1882 - 1888. [Abstract] [Full Text]
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B. M. Rajko Igic, V. Leray, P. A. Deddish, and E. G. Erdos Removal of Arg141 From the {alpha} Chain of Human Hemoglobin by Carboxypeptidases N and M Circ. Res., April 1, 1996; 78(4): 635 - 642. [Abstract] [Full Text]
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P. Matz, P. Weinstein, B. States, J. Honkaniemi, and F. R. Sharp Subarachnoid Injections of Lysed Blood Induce the hsp70 Stress Gene and Produce DNA Fragmentation in Focal Areas of the Rat Brain Stroke, March 1, 1996; 27(3): 504 - 513. [Abstract] [Full Text]
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J. B. Bederson, I. M. Germano, and L. Guarino Cortical Blood Flow and Cerebral Perfusion Pressure in a New Noncraniotomy Model of Subarachnoid Hemorrhage in the Rat Stroke, June 1, 1995; 26(6): 1086 - 1092. [Abstract] [Full Text]
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 H.-P. Haring, H.-K. Rotzer, H. Reindl, K. Berek, A. Kampfl, B. Pfausler, and E. Schmutzhard Time Course of Cerebral Blood Flow Velocity in Central Nervous System Infections: A Transcranial Doppler Sonography Study Arch Neurol, January 1, 1993; 50(1): 98 - 101. [Abstract] [PDF]
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F. Kehl, L. Cambj-Sapunar, K. G. Maier, N. Miyata, S. Kametani, H. Okamoto, A. G. Hudetz, M. L. Schulte, D. Zagorac, D. R. Harder, et al. 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1556 - H1565. [Abstract] [Full Text] [PDF]
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