Stroke, Vol 22, 993-996, Copyright © 1991 by American Heart Association
K Dozono, N Ishii, Y Nishihara and A Horie
We investigated selected features of lacunes in 1,086 necropsy cases.
Lacunes were found in brains from patients above the age of 40 years and
were most common in brains from persons in their sixties but decreased in
number in brains from older persons. The most common site of lacunes was
the frontal lobe white matter, followed by the putamen, pons, parietal lobe
white matter, thalamus, and caudate nucleus in descending order of
frequency. By dividing the 1,086 cases into three groups according to blood
pressure, we found more lacunes in the hypertensive and borderline
hypertensive groups than in the normotensive group; the average number of
lacunes per brain in each group was 3.61, 2.77, and 1.15, respectively.
Diastolic hypertension was more closely related to the number of lacunes
than was systolic hypertension. The extent of arteriolosclerosis of the
medullary arteries in the frontal lobe white matter was measured and
compared with the number of lacunes. There was a close correlation between
lacunes and arterioloslerosis in all age groups.
ARTICLES
An autopsy study of the incidence of lacunes in relation to age, hypertension, and arteriosclerosis
Department of Pathology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu-shi, Japan.
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