Stroke, Vol 23, 1701-1704, Copyright © 1992 by American Heart Association
HS Jorgensen, AM Plesner, P Hubbe and K Larsen
BACKGROUND AND PURPOSE: Stroke incidence declined until the end of the
1970s in the United States, and the decline continued into the 1980s in
Japan. The purpose of this study was to determine possible temporal changes
of stroke incidence in a European community. METHODS: A prospective stroke
registry was established in the community of Frederiksberg (population,
approximately 90,000), Denmark, in the two periods 1972-1974 and 1989-1990.
All patients suspected of stroke were clinically evaluated by a
neurologist. Only patients with first-ever stroke were included. Complete
case ascertainment was ensured by registration of both hospitalized and
nonhospitalized patients. Death certificates were also scrutinized.
RESULTS: A total of 927 patients with first-ever stroke was recorded. The
annual stroke incidence rate per 1,000 increased by 18% from 2.6 in
1972-1974 to 3.1 in 1989-1990 (p < 0.01). This increase was due solely
to a 42% increase in men, in whom stroke incidence rose from 2.1 to 3.0 (p
< 0.0005). Incidence was unchanged in women at 3.0 and 3.1,
respectively. The incidence rates from 1972-1974 were age and sex adjusted
to the 1990 population. After adjustment to the Danish population, stroke
incidence in Denmark was 2.0 for all, 2.3 for men, and 1.9 for women. In
the second study period computed tomography or necropsy was performed in
85% of cases; 2.4/1,000 had cerebral infarction; 0.20/1,000 had
intracerebral hemorrhage; and 0.02/1,000 had subarachnoid hemorrhage.
CONCLUSIONS: In a period when decline in stroke incidence has stopped in
the United States and has continued in Japan, a marked increase of stroke
incidence in Danish men was observed.
ARTICLES
Marked increase of stroke incidence in men between 1972 and 1990 in Frederiksberg, Denmark
Department of Neurology, Frederiksberg Hospital, Denmark.
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