Stroke, Vol 23, 175-180, Copyright © 1992 by American Heart Association
K Matsubayashi, K Shimada, A Kawamoto and T Ozawa
BACKGROUND AND PURPOSE: Controversies exist whether incidental
neuroradiological brain lesions in the elderly are associated with
depressed neuropsychological function. To address this important issue in a
cross-sectional study, we related brain lesions on magnetic resonance
imaging to a variety of cognitive and neurobehavioral function tests in an
independent, normal elderly population. METHODS: We studied 73 independent
asymptomatic elderly individuals (mean +/- SD age 70 +/- 6 years) to
determine the relations between degree of brain atrophy, location and
number of "lacunes," and grade of periventricular hyperintense lesions with
a variety of cognitive and neurobehavioral function scores. RESULTS: We
found that severity of neuroradiological changes increased while
neuropsychological function scores declined with age. After adjustment for
the effect of age, advanced periventricular hyperintensities, but not brain
atrophy or patchy "lacunar" lesions, were associated with declines in all
neuropsychological functions tested. CONCLUSION: We conclude that
incidental advanced periventricular diffuse or patchy white matter changes
may play a role in the development of cognitive and neurobehavioral
impairments in apparently normal elderly persons.
ARTICLES
Incidental brain lesions on magnetic resonance imaging and neurobehavioral functions in the apparently healthy elderly
Department of Medicine and Geriatrics, Kochi Medical School, Nankoku City, Japan.
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