Stroke, Vol 23, 221-223, Copyright © 1992 by American Heart Association
LM Brass, JL Isaacsohn, KR Merikangas and CD Robinette
BACKGROUND AND PURPOSE: Although there are strong genetic contributions to
coronary artery disease, only a few studies have considered heritable
influences on stroke. METHODS: We investigated the role of genetic factors
in stroke using the Twin Registry maintained by the National Academy of
Sciences-National Research Council. The registry includes 15,948 male twin
pairs born between 1917 and 1927. In 1985, 9,475 twins responded to a
mailed questionnaire, which covered vascular risk factors, cardiac events,
and stroke. RESULTS: Analysis of twin pairs in which both responded to the
questionnaire, and a question on stroke, indicated proband concordance
rates of 17.7% for monozygotic pairs and 3.6% for dizygotic pairs (relative
risk = 4.3; chi 2 = 4.94, df = 1; p less than 0.05). CONCLUSIONS: This
nearly fivefold increase in the prevalence of stroke among the monozygotic
compared with the dizygotic twin pairs suggests that genetic factors are
involved in the etiology of stroke. The twin study paradigm holds
considerable promise for identifying both genetic and environmental
influences on stroke.
ARTICLES
A study of twins and stroke
Department of Neurology, Yale University School of Medicine, New Haven, Conn. 06510.
This article has been cited by other articles:
 |
|
 |
|
  T. Janunger, S. Nilsson-Ardnor, P. -G. Wiklund, P. Lindgren, S. A. Escher, K. Lackovic, A. K. Nilsson, B. Stegmayr, K. Asplund, and D. Holmberg A novel stroke locus identified in a northern Sweden pedigree: Linkage to chromosome 9q31-33 Neurology, November 24, 2009; 73(21): 1767 - 1773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Luke, E. S. O'Meara, C. M. Rowland, D. Shiffman, L. A. Bare, A. R. Arellano, W.T. Longstreth Jr, T. Lumley, K. Rice, R. P. Tracy, et al. Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study Stroke, February 1, 2009; 40(2): 363 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-M. Brand-Herrmann Where Do We Go for Atherothrombotic Disease Genetics? Stroke, April 1, 2008; 39(4): 1070 - 1075. [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Goldstein, R. Adams, M. J. Alberts, L. J. Appel, L. M. Brass, C. D. Bushnell, A. Culebras, T. J. DeGraba, P. B. Gorelick, J. R. Guyton, et al. Primary Prevention of Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline. Circulation, June 20, 2006; 113(24): e873 - e923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Goldstein, R. Adams, M. J. Alberts, L. J. Appel, L. M. Brass, C. D. Bushnell, A. Culebras, T. J. DeGraba, P. B. Gorelick, J. R. Guyton, et al. Primary Prevention of Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council: Cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline. Stroke, June 1, 2006; 37(6): 1583 - 1633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dichgans and H. S. Markus Genetic Association Studies in Stroke: Methodological Issues and Proposed Standard Criteria Stroke, September 1, 2005; 36(9): 2027 - 2031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nilsson-Ardnor, P.-G. Wiklund, P. Lindgren, A. K. Nilsson, T. Janunger, S. A. Escher, B. Hallbeck, B. Stegmayr, K. Asplund, and D. Holmberg Linkage of Ischemic Stroke to the PDE4D Region on 5q in a Swedish Population Stroke, August 1, 2005; 36(8): 1666 - 1671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bevan, L. Porteous, M. Sitzer, and H.S. Markus Phosphodiesterase 4D Gene, Ischemic Stroke, and Asymptomatic Carotid Atherosclerosis Stroke, May 1, 2005; 36(5): 949 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H.C. Wong, I. I. Gottesman, and A. Petronis Phenotypic differences in genetically identical organisms: the epigenetic perspective Hum. Mol. Genet., April 15, 2005; 14(suppl_1): R11 - R18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Meschia, T. G. Brott, and R. D. Brown Jr Genetics of Cerebrovascular Disorders Mayo Clin. Proc., January 1, 2005; 80(1): 122 - 132. [Abstract] [PDF]
|
|
|
|
 |
|
 J. P. Casas, A. D. Hingorani, L. E. Bautista, and P. Sharma Meta-analysis of Genetic Studies in Ischemic Stroke: Thirty-two Genes Involving Approximately 18 000 Cases and 58 000 Controls Arch Neurol, November 1, 2004; 61(11): 1652 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Markus Genes for stroke J. Neurol. Neurosurg. Psychiatry, September 1, 2004; 75(9): 1229 - 1231. [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Uhl and R. W. Grow The Burden of Complex Genetics in Brain Disorders Arch Gen Psychiatry, March 1, 2004; 61(3): 223 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Flossmann, U. G.R. Schulz, and P. M. Rothwell Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke Stroke, January 1, 2004; 35(1): 212 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fornage, M. W. Swank, E. Boerwinkle, and P. A. Doris Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibility Physiol Genomics, September 29, 2003; 15(1): 75 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tentschert, S. Greisenegger, R. Wimmer, W. Lang, and W. Lalouschek Association of Parental History of Stroke With Clinical Parameters in Patients With Ischemic Stroke or Transient Ischemic Attack Stroke, September 1, 2003; 34(9): 2114 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Meschia, E. J. Atkinson, P. C. O'Brien, T. G. Brott, R. D. Brown Jr, and J. Hardy Familial Clustering of Stroke According to Proband Age at Onset of Presenting Ischemic Stroke Stroke, July 1, 2003; 34 (7): e89 - e91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jerrard-Dunne, G. Cloud, A. Hassan, and H. S. Markus Evaluating the Genetic Component of Ischemic Stroke Subtypes: A Family History Study Stroke, June 1, 2003; 34(6): 1364 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Driscoll, A. Hurlet, L. Styles, V. McKie, B. Files, N. Olivieri, C. Pegelow, B. Berman, R. Drachtman, K. Patel, et al. Stroke risk in siblings with sickle cell anemia Blood, March 15, 2003; 101(6): 2401 - 2404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hassan, P. C. Sham, and H. S. Markus Planning genetic studies in human stroke: Sample size estimates based on family history data Neurology, May 28, 2002; 58(10): 1483 - 1488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Hassan, A Lansbury, A J Catto, A Guthrie, J Spencer, C Craven, P J Grant, and J M Bamford Angiotensin converting enzyme insertion/deletion genotype is associated with leukoaraiosis in lacunar syndromes J. Neurol. Neurosurg. Psychiatry, March 1, 2002; 72(3): 343 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bak, D. Gaist, S. H. Sindrup, A. Skytthe, and K. Christensen Genetic Liability in Stroke: A Long-Term Follow-Up Study of Danish Twins Stroke, March 1, 2002; 33(3): 769 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Doris Hypertension Genetics, Single Nucleotide Polymorphisms, and the Common Disease:Common Variant Hypothesis Hypertension, February 1, 2002; 39(2): 323 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Catto Genetic aspects of the hemostatic system in cerebrovascular disease Neurology, September 1, 2001; 57(90002): S24 - 30. [Abstract] [Full Text]
|
|
|
|
|
|
G.J. Hademenos, M.J. Alberts, I. Awad, M. Mayberg, T. Shephard, A. Jagoda, R.E. Latchaw, H.W. Todd, K. Viste, R. Starke, et al. Advances in the genetics of cerebrovascular disease and stroke Neurology, April 24, 2001; 56(8): 997 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Morrison, P. A. Doris, A. R. Folsom, F. J. Nieto, E. Boerwinkle, and R. A. Hegele G-Protein {beta}3 Subunit and {{alpha}}-Adducin Polymorphisms and Risk of Subclinical and Clinical Stroke Editorial Comment : Candidate Genes for Stroke: If Elected, Will They Serve? Stroke, April 1, 2001; 32(4): 822 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hou, D. Osei-Hyiaman, H. Yu, Z. Ren, Z. Zhang, B. Wang, and S. Harada Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients Neurology, February 27, 2001; 56(4): 490 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Goldstein, R. Adams, K. Becker, C. D. Furberg, P. B. Gorelick, G. Hademenos, M. Hill, G. Howard, V. J. Howard, B. Jacobs, et al. Primary Prevention of Ischemic Stroke : A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association Circulation, January 2, 2001; 103(1): 163 - 182. [Full Text] [PDF]
|
|
|
|
|
|
L. B. Goldstein, R. Adams, K. Becker, C. D. Furberg, P. B. Gorelick, G. Hademenos, M. Hill, G. Howard, V. J. Howard, B. Jacobs, et al. Primary Prevention of Ischemic Stroke : A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association Stroke, January 1, 2001; 32(1): 280 - 299. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hassan and H. S. Markus Genetics and ischaemic stroke Brain, September 1, 2000; 123(9): 1784 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Meschia, T. G. Brott, F. E. Chukwudelunzu, J. Hardy, R. D. Brown Jr, I. Meissner, L. J. Hall, E. J. Atkinson, and P. C. O'Brien Verifying the Stroke-Free Phenotype by Structured Telephone Interview Stroke, May 1, 2000; 31(5): 1076 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nicolaou, A. L. DeStefano, I. Gavras, L. A. Cupples, A. J. Manolis, C. T. Baldwin, H. Gavras, and L. A. Farrer Genetic Predisposition to Stroke in Relatives of Hypertensives Stroke, February 1, 2000; 31(2): 487 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rubattu, M. A. Lee-Kirsch, P. DePaolis, R. Giliberti, B. Gigante, A. Lombardi, M. Volpe, and K. Lindpaintner Altered Structure, Regulation, and Function of the Gene Encoding the Atrial Natriuretic Peptide in the Stroke-Prone Spontaneously Hypertensive Rat Circ. Res., November 12, 1999; 85(10): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rubattu, P. Ridker, M. J. Stampfer, M. Volpe, C. H. Hennekens, and K. Lindpaintner The Gene Encoding Atrial Natriuretic Peptide and the Risk of Human Stroke Circulation, October 19, 1999; 100(16): 1722 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. MacLeod, M. T. Dahiyat, A. Cumming, D. Meiklejohn, D. Shaw, and D. St. Clair No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke Neurology, July 1, 1999; 53(2): 418 - 418. [Abstract] [Full Text]
|
|
|
|
|
|
E. Boerwinkle, P. A. Doris, and M. Fornage Field of Needs : The Genetics of Stroke Circulation, January 26, 1999; 99(3): 331 - 333. [Full Text] [PDF]
|
|
|
|
|
|
H. S. Markus, Y. Ruigrok, N. Ali, and J. F. Powell Endothelial Nitric Oxide Synthase Exon 7 Polymorphism, Ischemic Cerebrovascular Disease, and Carotid Atheroma Stroke, September 1, 1998; 29(9): 1908 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Carmelli, C. DeCarli, G. E. Swan, L. M. Jack, T. Reed, P. A. Wolf, and B. L. Miller Evidence For Genetic Variance in White Matter Hyperintensity Volume in Normal Elderly Male Twins Stroke, June 1, 1998; 29(6): 1177 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hiramoto, H. Yoshida, T. Imaizumi, N. Yoshimizu, and K. Satoh A Mutation in Plasma Platelet-Activating Factor Acetylhydrolase (Val279->Phe) is a Genetic Risk Factor for Stroke Stroke, December 1, 1997; 28(12): 2417 - 2420. [Abstract] [Full Text]
|
|
|
|
|
|
S. G. Wannamethee, A. G. Shaper, and S. Ebrahim History of Parental Death From Stroke or Heart Trouble and the Risk of Stroke in Middle-aged Men Stroke, September 1, 1996; 27(9): 1492 - 1498. [Abstract] [Full Text]
|
|
|
|
|
|
H. S. Markus, J. Barley, R. Lunt, J. M. Bland, S. Jeffery, N. D. Carter, and M. M. Brown Angiotensin-Converting Enzyme Gene Deletion Polymorphism : A New Risk Factor for Lacunar Stroke but not Carotid Atheroma Stroke, August 1, 1995; 26(8): 1329 - 1333. [Abstract] [Full Text]
|
|