Stroke, Vol 23, 576-582, Copyright © 1992 by American Heart Association
N van Bruggen, BM Cullen, MD King, M Doran, SR Williams, DG Gadian and JE Cremer
BACKGROUND AND PURPOSE: We sought to evaluate the application of T2-
weighted and diffusion-weighted magnetic resonance imaging techniques in
the study of a focal ischemic lesion in the rat brain. METHODS: Unilateral
cortical infarcts were induced using the photosensitive dye rose bengal and
560 nm light irradiation. Magnetic resonance images were recorded from a
total of 11 rats at selected intervals from 1.5 hours to several days after
induction of the lesion. Parallel experiments were performed in which Evans
blue dye was injected into the lesioned animals either immediately after
lesion induction (n = 11) or 1 hour before the animals were killed (n =
11). The second procedure was designed to show regions of blood-brain
barrier permeability to plasma proteins at the time of sacrifice, whereas
the first procedure showed the accumulation and subsequent dispersion of
plasma protein following disruption of the blood-brain barrier. RESULTS:
Regions of the cortex highlighted by the T2-weighted images corresponded
well to the pattern of dye staining seen from the first procedure while the
diffusion-weighted images showed visual correspondence with the staining
pattern obtained using the second procedure. CONCLUSIONS: These results
illustrate the complementary use of T2-weighted and diffusion-weighted
magnetic resonance imaging in discerning the pathophysiology of developing
lesions.
ARTICLES
T2- and diffusion-weighted magnetic resonance imaging of a focal ischemic lesion in rat brain
Department of Biophysics, Hunterian Institute, Royal College of Surgeons of England, London.
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