This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ziv, I. Articles by Sokolovsky, M. Search for Related Content PubMed PubMed Citation Articles by Ziv, I. Articles by Sokolovsky, M.

Stroke, Vol 23, 1014-1016, Copyright © 1992 by American Heart Association

ARTICLES

Increased plasma endothelin-1 in acute ischemic stroke

I Ziv, G Fleminger, R Djaldetti, A Achiron, E Melamed and M Sokolovsky
Department of Neurology, Beilinson Medical Center, Petah-Tiqva, Israel.

BACKGROUND AND PURPOSE: Endothelins are a recently discovered group of most powerful vasoconstrictor peptides. Endothelin-1 is produced by endothelial cells, and endothelin-3 is derived from neuronal tissue. Theoretically, endothelin-mediated vasoconstriction may enhance ischemic neuronal damage. This study aimed to measure plasma levels of both endothelins in patients with acute nonhemorrhagic cerebral infarction. SUMMARY OF REPORT: Plasma levels of endothelin-1 and endothelin-3 were measured by radioimmunoassay in 16 consecutive patients within the first 72 hours after the onset of nonhemorrhagic cerebral infarct, as diagnosed clinically and by computed tomography. There was a marked (fourfold) elevation in plasma endothelin-1 levels in the patients (median, 11.7 pg/ml; 25th and 75th centiles, 5.4 and 13.2 pg/ml) compared with those in a control group of 13 age-matched subjects (median, 2.56 pg/ml; 25th and 75th centiles, 2.4 and 3.0 pg/ml; p less than 0.0001). The first 24 hours after stroke onset were associated with higher endothelin-1 levels, and there was a trend to elevated levels with more severe neurological deficits. In all patients and controls endothelin-3 levels were below 0.5 pg/ml. CONCLUSIONS: Ischemic stroke is associated with acute and marked increases in plasma levels of endothelin-1. This may reflect enhanced production by damaged endothelial cells within the infarcted tissue. Local leakage of endothelin-1 may induce severe and prolonged constriction of collateral vessels and may therefore have a deleterious role in the pathogenesis and final outcome of cerebral infarction.

This article has been cited by other articles:

				M. R. Dashwood and J. C. S. Tsui The Effect of Acute Ischemia on ET-1 and Its Receptors in Patients with Underlying Chronic Ischemia of the Lower Limb. Experimental Biology and Medicine, June 1, 2006; 231(6): 802 - 805. [Abstract] [Full Text] [PDF]

				M. Henriksson, E. Stenman, and L. Edvinsson Intracellular Pathways Involved in Upregulation of Vascular Endothelin Type B Receptors in Cerebral Arteries of the Rat Stroke, June 1, 2003; 34(6): 1479 - 1483. [Abstract] [Full Text] [PDF]

				E. Stenman, M. Malmsjo, E. Uddman, G. Gido, T. Wieloch, and L. Edvinsson Cerebral Ischemia Upregulates Vascular Endothelin ETB Receptors in Rat Stroke, September 1, 2002; 33(9): 2311 - 2316. [Abstract] [Full Text] [PDF]

				Z. Alioglu, A. Orem, I. Bulbul, C. Boz, M. Ozmenoglu, and B. Vanizor Evaluation of Plasma Endothelin-1 Levels in Patients with Cerebral Infarction Angiology, January 1, 2002; 53(1): 77 - 82. [Abstract] [PDF]

				Y. Matsuo, S.-i. Mihara, M. Ninomiya, and M. Fujimoto Protective Effect of Endothelin Type A Receptor Antagonist on Brain Edema and Injury After Transient Middle Cerebral Artery Occlusion in Rats Stroke, September 1, 2001; 32(9): 2143 - 2148. [Abstract] [Full Text] [PDF]

				L. Mascia, L. Fedorko, D. J. Stewart, F. Mohamed, K. terBrugge, V. M. Ranieri, M. C. Wallace, and R. M. Pluta Temporal Relationship Between Endothelin-1 Concentrations and Cerebral Vasospasm in Patients With Aneurysmal Subarachnoid Hemorrhage Editorial Comment : Endothelin-1 in Vasospasm After SAH Stroke, May 1, 2001; 32(5): 1185 - 1190. [Abstract] [Full Text] [PDF]

				E. Haapaniemi, T. Tatlisumak, K. Hamel, L. Soinne, C. Lanni, T. J. Opgenorth, and M. Kaste Plasma Endothelin-1 Levels Neither Increase nor Correlate With Neurological Scores, Stroke Risk Factors, or Outcome in Patients With Ischemic Stroke Stroke, March 1, 2000; 31(3): 720 - 725. [Abstract] [Full Text] [PDF]

				L. N. Pierre, A. P. Davenport, and Z. S. Katusic Blockade and Reversal of Endothelin-Induced Constriction in Pial Arteries From Human Brain • Editorial Comment Stroke, March 1, 1999; 30(3): 638 - 643. [Abstract] [Full Text] [PDF]

				I. Anwaar, A. Gottsater, F. Lindgarde, and I. Mattiasson Increasing Plasma Neopterin and Persistent Plasma Endothelin During Follow-up After Acute Cerebral Ischemia Angiology, January 1, 1999; 50(1): 1 - 8. [Abstract] [PDF]

				D. G. F. Hamann Endothelins in Acute Ischemic Stroke Stroke, June 1, 1998; 29 (6): 1257 - 1258. [Full Text]

				T. Tatlisumak, R. A. D. Carano, K. Takano, T. J. Opgenorth, C. H. Sotak, M. Fisher, C. Y. Hsu, and W. Lin A Novel Endothelin Antagonist, A-127722, Attenuates Ischemic Lesion Size in Rats With Temporary Middle Cerebral Artery Occlusion : A Diffusion and Perfusion MRI Study • Editorial Comment: A Diffusion and Perfusion MRI Study Stroke, April 1, 1998; 29(4): 850 - 858. [Abstract] [Full Text] [PDF]

				Y. Lampl, G. Fleminger, R. Gilad, R. Galron, I. Sarova-Pinhas, and M. Sokolovsky Endothelin in Cerebrospinal Fluid and Plasma of Patients in the Early Stage of Ischemic Stroke Stroke, October 1, 1997; 28(10): 1951 - 1955. [Abstract] [Full Text]

				R. R. Wenzel, N. Duthiers, G. Noll, J. Bucher, U. Kaufmann, and T. F. Luscher Endothelin and Calcium Antagonists in the Skin Microcirculation of Patients With Coronary Artery Disease Circulation, August 1, 1996; 94(3): 316 - 322. [Abstract] [Full Text]

				E. R. Levin Endothelins N. Engl. J. Med., August 10, 1995; 333(6): 356 - 363. [Full Text] [PDF]