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Stroke, Vol 23, 1093-1098, Copyright © 1992 by American Heart Association
Y Ben-Shlomo, H Markowe, M Shipley and MG Marmot
BACKGROUND AND PURPOSE: Our aim in this study was to investigate the
relation between chronic alcohol consumption and stroke. METHODS: A
case-control study was carried out using two hospital-based control groups
and the results of a community-based survey of alcohol consumption.
Hospital-based control subjects were chosen either from "general" medical
admissions or a subset of "select" admissions that excluded possible
alcohol-related admissions. Cases were selected from hospital inpatients.
RESULTS: The relative risk for stroke associated with alcohol consumption
greater than 300 grams per week for general control subjects was 0.73 (95%
confidence interval [CI], 0.54-3.49) compared with 1.30 (95% CI, 0.42-4.05)
for select control subjects. The odds ratio was further increased to 1.93
(95% CI, 0.87-4.28) using data from the community-based survey. None of
these estimates were statistically significant. CONCLUSIONS: These results
illustrate how the risk associated with alcohol consumption varies
depending on the choice of control groups and may explain the contradictory
results from previous case-control studies. Because of different biases
associated with control selection, we believe that the results of this
study are consistent with those of other studies that demonstrate a modest
increased risk for stroke associated with alcohol consumption.
ARTICLES
Stroke risk from alcohol consumption using different control groups
Department of Epidemiology and Public Health, University College, London, UK.
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