Stroke, Vol 25, 808-813, Copyright © 1994 by American Heart Association
H Nakayama, HS Jorgensen, HO Raaschou and TS Olsen
BACKGROUND AND PURPOSE: This study was undertaken to elucidate whether and
how age influences stroke outcome. METHODS: This prospective and
community-based study comprised 515 consecutive acute stroke patients.
Computed tomographic scan was performed in 79% of patients. Activities of
daily living (ADL) and neurological status were assessed weekly during
hospital stay using the Barthel Index (BI) and the Scandinavian Stroke
Scale (SSS), respectively. Information regarding social condition and
comorbidity before stroke was also registered. A multiple regression model
was used to analyze the independent influence of age on stroke outcome.
RESULTS: Age was not related to the type of stroke lesion or infarct size.
However, age independently influenced initial BI (-4 points per 10 years, P
< .01), initial SSS (-2 points per 10 years, P = .01), and discharge BI
(-3 points per 10 years, P < .01). No independent influence of age was
found regarding mortality within 3 months, discharge SSS, length of
hospital stay, and discharge placement. ADL improvement was influenced
independently by age (-3 points per 10 years, P < .01), whereas age had
no influence on neurological improvement or on speed of recovery.
CONCLUSIONS: Age independently influences stroke outcome selectively in
ADL-related aspects (BI) but not in neurological aspects (SSS), suggesting
a poorer compensatory ability in elderly stroke patients. Therefore,
rehabilitation of elderly stroke patients should be focused more on ADL and
compensation rather than on the recovery of neurological status, and age
itself should not be a selection criterion for rehabilitation.
ARTICLES
The influence of age on stroke outcome. The Copenhagen Stroke Study
Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark.
This article has been cited by other articles:
 |
|
 |
|
  B. D. Roussel, R. Macrez, A. Jullienne, V. Agin, E. Maubert, L. Dauphinot, M.-C. Potier, L. Plawinski, H. Castel, Y. Hommet, et al. Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact Brain, August 1, 2009; 132(8): 2219 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Petrea, A. S. Beiser, S. Seshadri, M. Kelly-Hayes, C. S. Kase, and P. A. Wolf Gender Differences in Stroke Incidence and Poststroke Disability in the Framingham Heart Study Stroke, April 1, 2009; 40(4): 1032 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Manobianca, S. Zoccolella, A. Petruzzellis, A. Miccoli, and G. Logroscino Low Incidence of Stroke in Southern Italy: A Population-Based Study Stroke, November 1, 2008; 39(11): 2923 - 2928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Olsen, R. H. B. Christensen, L. P. Kammersgaard, and K. K. Andersen Higher Total Serum Cholesterol Levels Are Associated With Less Severe Strokes and Lower All-Cause Mortality: Ten-Year Follow-Up of Ischemic Strokes in the Copenhagen Stroke Study Stroke, October 1, 2007; 38(10): 2646 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Carandang, S. Seshadri, A. Beiser, M. Kelly-Hayes, C. S. Kase, W. B. Kannel, and P. A. Wolf Trends in Incidence, Lifetime Risk, Severity, and 30-Day Mortality of Stroke Over the Past 50 Years JAMA, December 27, 2006; 296(24): 2939 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Paolucci, M. Bragoni, P. Coiro, D. De Angelis, F. R. Fusco, D. Morelli, V. Venturiero, and L. Pratesi Is Sex a Prognostic Factor in Stroke Rehabilitation?: A Matched Comparison Stroke, December 1, 2006; 37(12): 2989 - 2994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ay, W. J. Koroshetz, M. Vangel, T. Benner, C. Melinosky, M. Zhu, N. Menezes, C. J. Lopez, and A. G. Sorensen Conversion of Ischemic Brain Tissue Into Infarction Increases With Age Stroke, December 1, 2005; 36(12): 2632 - 2636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. J. Durward, T. S. Ragnarsson, R. F. Reeder, J. L. Case, and C. A. Hughes Carotid Endarterectomy in Nonagenarians Arch Surg, July 1, 2005; 140(7): 625 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kastrau, M. Wolter, W. Huber, and F. Block Recovery From Aphasia After Hemicraniectomy for Infarction of the Speech-Dominant Hemisphere Stroke, April 1, 2005; 36(4): 825 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Paolucci, G. Antonucci, M. G. Grasso, M. Bragoni, P. Coiro, D. De Angelis, F. R. Fusco, D. Morelli, V. Venturiero, E. Troisi, et al. Functional Outcome of Ischemic and Hemorrhagic Stroke Patients After Inpatient Rehabilitation: A Matched Comparison Stroke, December 1, 2003; 34(12): 2861 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Appelros, I. Nydevik, A. Seiger, and A. Terent Predictors of Severe Stroke: Influence of Preexisting Dementia and Cardiac Disorders Stroke, October 1, 2002; 33(10): 2357 - 2362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bagg, A. P. Pombo, and W. Hopman Effect of Age on Functional Outcomes After Stroke Rehabilitation Stroke, January 1, 2002; 33(1): 179 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tilling, J. A.C. Sterne, A. G. Rudd, T. A. Glass, R. J. Wityk, and C. D.A. Wolfe A New Method for Predicting Recovery After Stroke Stroke, December 1, 2001; 32(12): 2867 - 2873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Copen, L. H. Schwamm, R. G. Gonzalez, O. Wu, C. B. Harmath, P. W. Schaefer, W. J. Koroshetz, and A. G. Sorensen Ischemic Stroke: Effects of Etiology and Patient Age on the Time Course of the Core Apparent Diffusion Coefficient Radiology, October 1, 2001; 221(1): 27 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Alexander, C. Bugge, and S. Hagen What is the association between the different components of stroke rehabilitation and health outcomes? Clinical Rehabilitation, February 1, 2001; 15(2): 207 - 215. [Abstract] [PDF]
|
|
|
|
|
|
A. Di Carlo, M. Lamassa, G. Pracucci, A. M. Basile, G. Trefoloni, P. Vanni, C. D. A. Wolfe, K. Tilling, S. Ebrahim, and D. Inzitari Stroke in the Very Old : Clinical Presentation and Determinants of 3-Month Functional Outcome: A European Perspective Stroke, November 1, 1999; 30(11): 2313 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Jorgensen, J. Reith, H. Nakayama, L. P. Kammersgaard, H. O. Raaschou, and T. S. Olsen What Determines Good Recovery in Patients With the Most Severe Strokes? : The Copenhagen Stroke Study Stroke, October 1, 1999; 30(10): 2008 - 2012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Thommessen, E. Bautz-Holter, and K. Laake Predictors of outcome of rehabilitation of elderly stroke patients in a geriatric ward Clinical Rehabilitation, February 1, 1999; 13(2): 123 - 128. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Ramasubbu, R. G. Robinson, A. J. Flint, T. Kosier, and T. R. Price Functional Impairment Associated With Acute Poststroke Depression: The Stroke Data Bank Study J Neuropsychiatry Clin Neurosci, February 1, 1998; 10(1): 26 - 33. [Abstract] [Full Text]
|
|
|
|
|
|
T. Sim, C. Lum, F. K Sze, K. Or, and J. Woo Outcome after stroke rehabilitation in Hong Kong Clinical Rehabilitation, August 1, 1997; 11(3): 236 - 242. [Abstract] [PDF]
|
|
|
|
|
|
H. S. Jorgensen, H. Nakayama, H. O. Raaschou, and T. S. Olsen Acute Stroke Care and Rehabilitation: An Analysis of the Direct Cost and Its Clinical and Social Determinants : The Copenhagen Stroke Study Stroke, June 1, 1997; 28(6): 1138 - 1141. [Abstract] [Full Text]
|
|
|
|
|
|
T. B. Wyller, K. M. Sodring, U. Sveen, A. E. Ljunggren, and E. Bautz-Holter Are there gender differences in functional outcome after stroke? Clinical Rehabilitation, May 1, 1997; 11(2): 171 - 179. [Abstract] [PDF]
|
|
|
|
|
|
G. R. Sutherland, G. A. Dix, R. N. Auer, and R. C. Koehler Effect of Age in Rodent Models of Focal and Forebrain Ischemia Stroke, September 1, 1996; 27(9): 1663 - 1668. [Abstract] [Full Text]
|
|