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(Stroke. 1995;26:7-13.)
© 1995 American Heart Association, Inc.

Articles

Risk of Stroke With Mitral Valve Prolapse in Population-Based Cohort Study

Anthony J. Orencia, MD, PhD; George W. Petty, MD; Bijoy K. Khandheria, MD; John F. Annegers, PhD; David J. Ballard, MD, PhD; JoRean D. Sicks, MS; W. Michael O'Fallon, PhD Jack P. Whisnant, MD

From the Departments of Health Sciences Research (A.J.O., D.J.B., J.D.S., W.M.O., J.P.W.) and Neurology (G.W.P.) and the Division of Cardiovascular Diseases and Internal Medicine (B.K.K.), Mayo Clinic and Mayo Foundation, Rochester, Minn; and the Department of Health Sciences Research (J.F.A.), School of Public Health, University of Texas, Houston.

Background and Purpose The purpose of this study was to clarify whether mitral valve prolapse increases the subsequent risk of stroke.

Methods A historical cohort study was conducted on 1079 residents of Olmsted County, Minnesota, who had an initial echocardiographic diagnosis of mitral valve prolapse between 1975 and 1989 without prior stroke or transient ischemic attack and who were followed up for first stroke occurrence.

Results There was an overall twofold increase in the incidence of stroke among individuals with mitral valve prolapse relative to the reference population (standardized morbidity ratio, 2.1; 95% confidence interval, 1.3 to 3.2). Sex, duration of follow-up from the diagnosis of mitral valve prolapse, or calendar year of initial diagnosis did not modify the association. Within the cohort of patients who were at least 35 years old at diagnosis of mitral valve prolapse, a time-dependent proportional-hazards multivariate model and a person-years analysis revealed that age, ischemic heart disease, congestive heart failure, and diabetes mellitus were important determinants for stroke when person-years of observation after mitral valve replacement were excluded. Among seven persons with mitral valve replacement, three strokes occurred in 24 person-years of follow-up. For those with an auscultatory diagnosis of mitral valve prolapse only as the indication for echocardiography (44%), the risk of stroke relative to the population was 1.0 (95% confidence interval, 0.2 to 2.9); for those with another cardiac diagnosis, the standardized morbidity ratio was 2.5 (95% confidence interval, 1.5 to 4.0).

Conclusions Individuals with uncomplicated mitral valve prolapse did not have an increased risk of stroke, although a small increase in the risk may not have been detected.

Key Words: echocardiography • mitral valve prolapse • morbidity • risk factors

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