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(Stroke. 1995;26:1358-1360.)
© 1995 American Heart Association, Inc.

Articles

Spontaneous Early Improvement Following Ischemic Stroke

John F. Rothrock, MD; Wayne M. Clark, MD Patrick D. Lyden, MD

From the Department of Neurology, University of South Alabama, Mobile, Ala (J.F.R.); the Department of Neurology, Oregon Health Sciences University, Portland, Ore (W.M.C.); and the Department of Neurology, University of California at San Diego (P.D.L.).

Correspondence to Dr Rothrock, Department of Neurology, University of South Alabama, 2451 Fillingim St, MCSB 1155, Mobile, AL 36617.

Background and Purpose Recognizing that early spontaneous neurological improvement not uncommonly follows acute ischemic stroke, we conducted this study to determine the incidence of such improvement and its potential relation to stroke etiology.

Methods We prospectively evaluated 68 patients who presented within 12 hours after ischemic stroke, exhibited moderate or severe new functional neurological deficit acutely, and received either no stroke-specific therapy or only antiplatelet therapy over the ensuing week. We reexamined all patients 1 week after stroke onset.

Results Sixteen (24%) of the 68 patients improved to the point of having no or mild functional neurological deficit at 1 week. Patients with lacunar stroke were more likely to enjoy early spontaneous improvement (8/22=36% versus 8/46=17%), but this difference did not reach statistical significance (P=.15).

Conclusions Early spontaneous improvement after ischemic stroke may occur in a substantial proportion of patients and more commonly after lacunar stroke. Even so, the majority of patients with acutely disabling stroke will remain significantly impaired 1 week after stroke onset.

Key Words: cerebral infarction • classification • prognosis

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