This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Itoh, Y. Articles by Otomo, E. Search for Related Content PubMed PubMed Citation Articles by Itoh, Y. Articles by Otomo, E.

(Stroke. 1996;27:216-218.)
© 1996 American Heart Association, Inc.

Articles

Influence of Apolipoprotein E Genotype on Cerebral Amyloid Angiopathy in the Elderly

Yoshinori Itoh, MD; Masahito Yamada, MD; Naomi Suematsu, MD; Masaaki Matsushita, MD Eiichi Otomo, MD

From the Departments of Internal Medicine (Y.I., E.O.) and Pathology (N.S.), Yokufukai Geriatric Hospital; the Department of Neurology, Tokyo Medical and Dental University (M.Y.); and the Department of Psychiatry, Faculty of Medicine, University of Tokyo (M.M.), Tokyo, Japan.

Correspondence to Yoshinori Itoh MD, Department of Internal Medicine, Yokufukai Geriatric Hospital, 1-12-1 Takaido-nishi, Suginami-ku, Tokyo 168, Japan.

Background and Purpose The inheritance of the 4 allele of the apolipoprotein E gene (APOE) is associated with increased risk of developing dementia of the Alzheimer type (DAT). We have investigated whether the APOE genotype influences the severity of cerebral amyloid angiopathy (CAA) in elderly individuals with or without DAT.

Methods From a consecutive autopsy series, we studied 88 patients (85.2±8.1 years) without degenerative disorders other than DAT. The percentages of amyloid-laden vessels in the occipital lobes were calculated and compared between APOE genotypes.

Results For 3/3 and 3/4 genotypes, there was a trend toward increased CAA in 3/4 individuals for non-DAT and conversely in 3/3 individuals for DAT patients, but these did not achieve significance.

Conclusions The present study suggests that the 4 allele is not a strong risk factor for CAA in elderly people.

Key Words: aging • Alzheimer's disease • amyloid • apolipoproteins

This article has been cited by other articles:

				T Hamaguchi, S Okino, N Sodeyama, Y Itoh, A Takahashi, E Otomo, M Matsushita, H Mizusawa, and M Yamada Association of a polymorphism of the transforming growth factor-{beta}1 gene with cerebral amyloid angiopathy J. Neurol. Neurosurg. Psychiatry, May 1, 2005; 76(5): 696 - 699. [Abstract] [Full Text] [PDF]

				J Tian, J Shi, K Bailey, C L Lendon, S M Pickering-Brown, and D M A Mann Association between apolipoprotein E e4 allele and arteriosclerosis, cerebral amyloid angiopathy, and cerebral white matter damage in Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, May 1, 2004; 75(5): 696 - 699. [Abstract] [Full Text] [PDF]

				M. Yamada, N. Sodeyama, Y. Itoh, E. Otomo, M. Matsushita, and H. Mizusawa No Association of Paraoxonase Genotype or Atherosclerosis With Cerebral Amyloid Angiopathy Stroke, April 1, 2002; 33(4): 896 - 900. [Abstract] [Full Text] [PDF]

				M. Yamada, N. Sodeyama, Y. Itoh, N. Suematsu, E. Otomo, M. Matsushita, and H. Mizusawa A Deletion Polymorphism of {alpha}2-Macroglobulin Gene and Cerebral Amyloid Angiopathy Stroke, November 1, 1999; 30 (11): 2277 - 2279. [Abstract] [Full Text] [PDF]

				M. Yamada, N. Sodeyama, Y. Itoh, N. Suematsu, E. Otomo, M. Matsushita, and H. Mizusawa Butyrylcholinesterase K Variant and Cerebral Amyloid Angiopathy Stroke, December 1, 1998; 29(12): 2488 - 2490. [Abstract] [Full Text] [PDF]

				M. Yamada, N. Sodeyama, Y. Itoh, N. Suematsu, E. Otomo, M. Matsushita, and H. Mizusawa Association of Presenilin-1 Polymorphism With Cerebral Amyloid Angiopathy in the Elderly Stroke, November 1, 1997; 28(11): 2219 - 2221. [Abstract] [Full Text]