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(Stroke. 1996;27:612-616.)
© 1996 American Heart Association, Inc.
Articles |
Improvement in Cerebral Hemodynamics After Carotid Angioplasty
From the Department of Neurology, King's College School of Medicine and Dentistry (H.S.M.); Division of Clinical Neuroscience, St George's Hospital Medical School (H.S.M, M.M.B.); Department of Neuroradiology, Atkinson Morley's Hospital (A.C.); and Departments of Radiology (T.B.) and Vascular Surgery (R.T.), St George's Hospital, London, UK.
Correspondence to Dr Hugh Markus, Department of Neurology, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK.
Background and Purpose Carotid percutaneous transluminal angioplasty (PTA) may offer an alternative treatment to carotid endarterectomy. However, in contrast to carotid endarterectomy, which has been shown to normalize impaired cerebral hemodynamics, the effects of carotid PTA are unknown. Therefore, we prospectively studied the effect of carotid PTA on both perioperative and postoperative cerebral hemodynamics.
Methods Eleven patients undergoing carotid PTA for symptomatic carotid artery stenosis were prospectively studied. Transcranial Doppler recordings from the ipsilateral middle cerebral artery (MCA) were performed during the procedure. In addition, MCA blood flow velocity and CO2 reactivity were determined before PTA and at 2 days, 1 month, and 6 months after the procedure. The results were compared with those in 11 similar patients undergoing carotid endarterectomy in whom measurements were performed before and 1 month after the operation.
Results During carotid PTA, in 2 of 11 patients during passage of the balloon catheter through the stenosis, MCA blood flow velocity fell transiently. In 6 of 11 patients there was a reduction in flow velocity (>50%) during balloon deflation, but this lasted only a few seconds. After the procedure there was a significant improvement in ipsilateral hypercapnic reactivity: preoperative value, 59.8±42.2% (mean±SD); 2 days, 77.9±31.4%; 1 month, 88.7±45.0%; 6 months, 89.8±33.9%; and (ANOVA P=.003) preoperative value versus 1 month, P<.02; versus 6 months, P<.02. In all cases in which reactivity was significantly impaired preoperatively, it returned to the normal range. Pulsatility index also increased significantly: preoperative value, 0.827±0.251 (mean±SD); 2 days, 0.992±0.262 (P=.002). Contralateral MCA hypercapnic reactivity also improved after carotid PTA. There was a similar improvement in ipsilateral hypercapnic reactivity after carotid endarterectomy.
Conclusions Carotid PTA results in a normalization of impaired hemodynamics, as assessed by CO2 reactivity. The degree of improvement is similar to that seen after carotid endarterectomy.
Key Words: angioplasty, transluminal • carotid artery diseases • cerebral blood flow • ultrasonics
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