(Stroke. 1997;28:1283-1288.)
© 1997 American Heart Association, Inc.
Articles |
Nitric Oxide Synthase in Models of Focal Ischemia
From the Departments of Neurology (A.F.S., T.M.D., V.L.D.), Neuroscience (T.M.D., V.L.D.), and Physiology (V.L.D.), Johns Hopkins University School of Medicine, Baltimore, Md.
Correspondence to Valina L. Dawson, PhD, Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Path 2-210, Baltimore, MD 21287. E-mail: valina_dawson{at}qmail.bs.jhu.edu
Background and Purpose Cessation of blood flow to the brain, for even a few minutes, sets in motion a potential reversible cascade of events resulting in neuronal cell death. Oxygen free radicals and oxidants appear to play an important role in central nervous system injury after cerebral ischemia and reperfusion. Recently, divergent roles for the newly identified neuronal messenger molecule and oxygen radical, nitric oxide (NO), have been identified in various models of cerebral ischemia. Because of the chemical and physical properties of NO, the numerous physiological activities it mediates, and the lack of specific agents to modulate the activity of the different isoforms of NO synthase (NOS), reports regarding the role of NO in focal cerebral ischemia have been confounding and often conflicting. Recent advances in pharmacology and the development of transgenic knockout mice specific for the different isoforms of NOS have advanced our knowledge and clarified the role of NO in cerebral ischemia.
Methods Animal models of focal ischemia employ occlusion of nutrient cerebral vessels, most commonly the middle cerebral artery. Primary cortical cultures are exposed to excitotoxic or ischemic conditions, and the activities of NOS isoforms or NO production are evaluated. Transgenic mice lacking expression of either the neuronal isoform of NOS (nNOS), the endothelial isoform of NOS (eNOS), or the immunologic isoform of NOS (iNOS) have been examined in models of excitotoxic injury and ischemia.
Results Excitotoxic or ischemic conditions excessively activate nNOS, resulting in concentrations of NO that are toxic to surrounding neurons. Conversely, NO generated from eNOS is critical in maintaining cerebral blood flow and reducing infarct volume. iNOS, which is not normally present in healthy tissue, is induced shortly after ischemia and contributes to secondary late-phase damage.
Conclusions Pharmacological and genetic approaches have significantly advanced our knowledge regarding the role of NO and the different NOS isoforms in focal cerebral ischemia. nNOS and iNOS play key roles in neurodegeneration, while eNOS plays a prominent role in maintaining cerebral blood flow and preventing neuronal injury.
Key Words: cerebral ischemia • free radicals • nitric oxide • glutamates • neurotoxins • oxidants
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|
|
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|
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|
|
|
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|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 H S Markus Cerebral perfusion and stroke J. Neurol. Neurosurg. Psychiatry, March 1, 2004; 75(3): 353 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 D. D. Waters, G. G. Schwartz, A. G. Olsson, A. Zeiher, M. F. Oliver, P. Ganz, M. Ezekowitz, B. R. Chaitman, S. J. Leslie, T. Stern, et al. Effects of Atorvastatin on Stroke in Patients With Unstable Angina or Non-Q-Wave Myocardial Infarction: A Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Substudy Circulation, September 24, 2002; 106(13): 1690 - 1695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Peeters-Scholte, J. Koster, W. Veldhuis, E. van den Tweel, C. Zhu, N. Kops, K. Blomgren, D. Bar, S. van Buul-Offers, H. Hagberg, et al. Neuroprotection by Selective Nitric Oxide Synthase Inhibition at 24 Hours After Perinatal Hypoxia-Ischemia Stroke, September 1, 2002; 33(9): 2304 - 2310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yang, T. F. Witham, L. Villa, M. Erff, J. Attanucci, S. Watkins, D. Kondziolka, H. Okada, I. F. Pollack, and W. H. Chambers Glioma-associated Hyaluronan Induces Apoptosis in Dendritic Cells via Inducible Nitric Oxide Synthase: Implications for the Use of Dendritic Cells for Therapy of Gliomas Cancer Res., May 1, 2002; 62(9): 2583 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Krishnadasan, C. R. Hampton, J. Griscavage-Ennis, R. J. Dabal, and E. D. Verrier Molecular Mechanisms of Neurologic Injury Following Cardiopulmonary Bypass Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2002; 6(1): 43 - 53. [Abstract] [PDF]
|
|
|
|
|
|
T. Goyagi, S. Goto, A. Bhardwaj, V. L. Dawson, P. D. Hurn, and J. R. Kirsch Neuroprotective Effect of {{sigma}}1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine (PPBP) Is Linked to Reduced Neuronal Nitric Oxide Production Stroke, July 1, 2001; 32(7): 1613 - 1620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Brooks, X. Gu, S. Samuel, D. M. Marcus, M. Bartoli, P. L. Huang, and R. B. Caldwell Reduced Severity of Oxygen-Induced Retinopathy in eNOS-Deficient Mice Invest. Ophthalmol. Vis. Sci., January 1, 2001; 42(1): 222 - 228. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Wagle and J. P. Singh Fibroblast Growth Factor Protects Nitric Oxide-Induced Apoptosis in Neuronal SHSY-5Y Cells J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 889 - 895. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Hassan and H. S. Markus Genetics and ischaemic stroke Brain, September 1, 2000; 123(9): 1784 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sasaki, M. Gonzalez-Zulueta, H. Huang, W. J. Herring, S. Ahn, D. D. Ginty, V. L. Dawson, and T. M. Dawson Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism PNAS, July 18, 2000; 97(15): 8617 - 8622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Johanson, H. M. Sarau, J. J. Foley, and J. R. Slemmon Calmodulin-Binding Peptide PEP-19 Modulates Activation of Calmodulin Kinase II In Situ J. Neurosci., April 15, 2000; 20(8): 2860 - 2866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McMillan, M. Adler, D. S. Auld, J. J. Baldwin, E. Blasko, L. J. Browne, D. Chelsky, D. Davey, R. E. Dolle, K. A. Eagen, et al. Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry PNAS, February 15, 2000; 97(4): 1506 - 1511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shareef, A. Sawada, and A. H. Neufeld Isoforms of Nitric Oxide Synthase in the Optic Nerves of Rat Eyes with Chronic Moderately Elevated Intraocular Pressure Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2884 - 2891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lin and S. Roth Ischemic Preconditioning Attenuates Hypoperfusion after Retinal Ischemia in Rats Invest. Ophthalmol. Vis. Sci., November 1, 1999; 40(12): 2925 - 2931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lipton Ischemic Cell Death in Brain Neurons Physiol Rev, October 1, 1999; 79(4): 1431 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gbadegesin, S. Vicini, S. J. Hewett, D. A. Wink, M. Espey, R. M. Pluta, and C. A. Colton Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death Am J Physiol Cell Physiol, October 1, 1999; 277(4): C673 - C683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Dawson Potent neuroprotectants linked to bifunctional inhibition PNAS, September 14, 1999; 96(19): 10557 - 10558. [Full Text] [PDF]
|
|
|
|
|
|
P.-E. Chabrier, M. Auguet, B. Spinnewyn, S. Auvin, S. Cornet, C. Demerle-Pallardy, C. Guilmard-Favre, J.-G. Marin, B. Pignol, V. Gillard-Roubert, et al. BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: A promising neuroprotective strategy PNAS, September 14, 1999; 96(19): 10824 - 10829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ling, C. Edelstein, P. Gengaro, X. Meng, S. Lucia, M. Knotek, A. Wangsiripaisan, Y. Shi, and R. Schrier Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice Am J Physiol Renal Physiol, September 1, 1999; 277(3): F383 - F390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Feng, D. M. Stern, and J. Pile-Spellman Human Endothelium: Endovascular Biopsy and Molecular Analysis Radiology, September 1, 1999; 212(3): 655 - 664. [Abstract] [Full Text]
|
|
|
|
|
|
C. J. Vaughan and N. Delanty Neuroprotective Properties of Statins in Cerebral Ischemia and Stroke Stroke, September 1, 1999; 30(9): 1969 - 1973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Davis and D. Barer Neuroprotection in acute ischaemic stroke. II: Clinical potential Vascular Medicine, August 1, 1999; 4(3): 149 - 163. [Abstract] [PDF]
|
|
|
|
 |
|
 S. I. Savitz and D. M. Rosenbaum Review : Gene Expression after Cerebral Ischemia Neuroscientist, July 1, 1999; 5(4): 238 - 253. [Abstract] [PDF]
|
|
|
|
 |
|
 M. J. MacLeod, M. T. Dahiyat, A. Cumming, D. Meiklejohn, D. Shaw, and D. St. Clair No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke Neurology, July 1, 1999; 53(2): 418 - 418. [Abstract] [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
B. L. Firestein and D. S. Bredt Interaction of Neuronal Nitric-oxide Synthase and Phosphofructokinase-M J. Biol. Chem., April 9, 1999; 274(15): 10545 - 10550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Bednar and C. E. Gross Antiplatelet Therapy in Acute Cerebral Ischemia Stroke, April 1, 1999; 30(4): 887 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lei, N. Adachi, T. Nagaro, T. Arai, and R. C. Koehler Nitric Oxide Production in the CA1 Field of the Gerbil Hippocampus After Transient Forebrain Ischemia : Effects of 7-Nitroindazole and NG-Nitro-L-Arginine Methyl Ester • Editorial Comment: Effects of 7-Nitroindazole and NG-Nitro-L-Arginine Methyl Ester Stroke, March 1, 1999; 30(3): 669 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Fan, Q. Zhang, M. Li, H. Tochio, T. Yamazaki, M. Shimizu, and M. Zhang Protein Inhibitor of Neuronal Nitric-oxide Synthase, PIN, Binds to a 17-Amino Acid Residue Fragment of the Enzyme J. Biol. Chem., December 11, 1998; 273(50): 33472 - 33481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. D. Lam, A. Bhardwaj, M. T. O'Connell, D. F. Hanley, R. J. Traystman, and M. V. Sofroniew Nerve growth factor rapidly suppresses basal, NMDA-evoked, and AMPA-evoked nitric oxide synthase activity in rat hippocampus in vivo PNAS, September 1, 1998; 95(18): 10926 - 10931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Markus, Y. Ruigrok, N. Ali, and J. F. Powell Endothelial Nitric Oxide Synthase Exon 7 Polymorphism, Ischemic Cerebrovascular Disease, and Carotid Atheroma Stroke, September 1, 1998; 29(9): 1908 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Förstermann, J.-p. Boissel, and H. Kleinert Expressional control of the `constitutive' isoforms of nitric oxide synthase (NOS I and NOS III) FASEB J, July 1, 1998; 12(10): 773 - 790. [Abstract] [Full Text]
|
|
|
|
|
|
F. Esch, K.-I Lin, A. Hills, K. Zaman, J. M. Baraban, S. Chatterjee, L. Rubin, D. E. Ash, and R. R. Ratan Purification of a Multipotent Antideath Activity from Bovine Liver and Its Identification as Arginase: Nitric Oxide-Independent Inhibition of Neuronal Apoptosis J. Neurosci., June 1, 1998; 18(11): 4083 - 4095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nanri, C. Montecot, V. Springhetti, J. Seylaz, E. Pinard, and W. D. Dietrich The Selective Inhibitor of Neuronal Nitric Oxide Synthase, 7-Nitroindazole, Reduces the Delayed Neuronal Damage Due to Forebrain Ischemia in Rats • Editorial Comment Stroke, June 1, 1998; 29(6): 1248 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Yun, M. Gonzalez-Zulueta, V. L. Dawson, and T. M. Dawson Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras PNAS, May 12, 1998; 95(10): 5773 - 5778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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D. Furling, O. Ghribi, A. Lahsaini, M.-E. Mirault, and G. Massicotte Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice PNAS, April 11, 2000; 97(8): 4351 - 4356. [Abstract] [Full Text] [PDF]
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