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(Stroke. 1998;29:2646-2648.)
© 1998 American Heart Association, Inc.
Short Communication |
Stroke Patterns of Internal Carotid Artery Dissection in 40 Patients
From the Departments of Neurology and Neuroradiology, Lille (C.L., D.D.) and Besançon (T.M., L.T., D.C.) University Hospitals, France.
Abstract
Background and Purpose—Internal
carotid artery dissection (ICAD) is a frequent cause of
ischemic stroke in young patients. Whether cerebral
ischemia is of embolic or hemodynamic origin
remains to be determined. Heparin is often administered in ICAD;
however, a drug trial can hardly be conducted because of the low
recurrence rate after the acute stage. Therefore, the best
therapeutic approach should be determined on the basis of the presumed
mechanism of cerebral ischemia. One way to approach the
mechanism of stroke in ICAD is to determine stroke patterns. We
postulated that most cortical and large subcortical infarcts (
15
mm) are of embolic origin and that small subcortical infarcts
(<15 mm) and junctional infarcts are not. The aim of our study
was to determine the stroke patterns in 40 consecutive patients
with ICAD.
Methods—The patients (26 women and 14 men; mean age, 42.8 years) had a total of 65 ICADs. Seventeen patients were free of any vascular risk factor. CT scans, MRI scans, and angiographic features were analyzed by observers who were blinded to the clinical findings.
Results—We found 34 cortical infarcts, 25 large subcortical infarcts, 1 small subcortical infarct, and 5 junctional infarcts.
Conclusions—Most infarcts related to ICAD are cortical infarcts or large subcortical infarcts; small subcortical infarcts and junctional infarcts are infrequent. Therefore, these findings suggest that most infarcts occurring in carotid artery dissection (CAD) are probably embolic rather than hemodynamic in origin. According to this presumed mechanism, anticoagulation seems a logical treatment at the early stage of CAD.
Key Words: cerebrovascular disorders • dissection • internal carotid artery • stroke • stroke classification
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