From the Department of Neurology, University of Tübingen (Germany).
Background and Purpose—During the
past decade, transcranial Doppler sonography has widely
been used to assess blood flow velocities in the basal intracranial
arteries and cerebrovascular reactivity (CR) to various stimuli.
Although numerous studies have shown a decline of cerebral blood flow
velocity with age, the age dependency of CR, including cerebrovascular
CO2 reactivity, however, is controversial. Recently, we
have reported a significant sex-related difference in CR, stressing the
need to study the relation between normal aging and CR in both
sexes separately.
Methods—By means of transcranial Doppler
sonography, CR was determined in 100 healthy, nonsmoking volunteers
(age 20 to 70 years, 10 men and 10 women per decade).
Results—In men, no change of CR with increasing age could be
observed (P=0.98). In contrast, CR in women declined
significantly, with a step decrease from the 4th to the 5th decades
(F=4.413; P<0.01) and was significantly higher in the
3rd and 4th compared with the 5th, 6th, and 7th decades
(P<0.05). Information on hormone replacement therapy
(HRT) in women of the 6th and 7th decades was obtained retrospectively.
HRT was associated with enhanced CR (HRT, n=7 versus non-HRT, n=13;
P<0.001), with values similar to those found in
premenopausal women.
Conclusions—There are no changes of CR during normal aging in
men, whereas CR declines significantly from the 4th to the 5th decades
in women. HRT in postmenopausal women appears to enhance CR.
© 1998 American Heart Association, Inc.
Original Contributions
Changes of Cerebrovascular CO2 Reactivity During Normal Aging
Key Words: carbon dioxide • cerebral blood flow velocity • ultrasonography, Doppler, transcranial
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