From the Department of Physiology and Pharmacology (J.C., N.W., A.D.K.)
and Department of Neurology (J.C., T.A.T., A.D.K., N.M.B.), Tel Aviv Medical
Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Correspondence to Dr N.M. Bornstein, Department of Neurology, Tel Aviv Medical Center, 6 Weizmann St, Tel Aviv, Israel.
Background and Purpose—There is a
growing interest in the use of genetic markers in the differential
diagnosis of dementia. In the current study we examined the usefulness
of genetic risk factors for vascular disease as markers for vascular
dementia (VD).
Methods—The groups included 41 patients with VD, 49 patients with
dementia of the Alzheimer's type, and 40 age-matched control
subjects without dementia. These patients were genotyped for
vascular disease–associated polymorphisms in the genes coding for
methylenetetrahydrofolate reductase
(MTHFR), angiotensin-converting enzyme (ACE), factor V
Leiden (FVL), and a common genetic risk factor for AD, apolipoprotein E
Results—There was no significant association between ACE, MTHFR,
and FVL genotypes with VD whether compared with subjects with
AD or with control subjects. There was a higher frequency of APOE
Conclusions—VD is not associated with the genetic risk factors
for vascular disease examined in this study, indicating that the
pathogenesis of VD may differ from other vascular diseases.
© 1998 American Heart Association, Inc.
Original Contributions
ACE, MTHFR, Factor V Leiden, and APOE Polymorphisms in Patients With Vascular and Alzheimer's Dementia
4 (APOE 4). 4
alleles in patients with AD (30%, P=0.016) and VD
(26%, P=0.07) compared with control subjects
(15%).
Key Words: angiotensin-converting enzymes • apolipoprotein E • dementia • factor V Leiden • methylenetetrahydrofolate reductase
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