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(Stroke. 1972;3:553.)
© 1972 American Heart Association, Inc.

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Cerebral Microangiography After Hypocarbia and Hypercarbia

Timothy Harrington M.D.¹ Giovanni Di Chiro M.D.²

¹ Section on Neuroradiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health Bethesda, Maryland, 20014
² Section on Neuroradiology, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, 20014

Ischemic infarction was obtained in the basal ganglia and internal capsule of the Rhesus monkey by clipping the middle cerebral artery at its origin through a transorbital approach.

The postmortem microvasculature was demonstrated using microtized barium (Micropaque) and soft x-ray technology. The effects on this microvasculature induced by antemortem variations in Pa_coco2 in tne normal and the acutely infarcted animal were studied. Microangiography was shown to be useful in the study of dynamic vascular changes in the deep structures of the ischemic brain.

Note:

Dr. Harrington is the recipient of an NINDS special traineeship grant, No. 1F11NS2513-01.

Key Words: cerebral infarction • microvasculature