This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Larner, A. J. Articles by Scaravilli, F. Search for Related Content PubMed PubMed Citation Articles by Larner, A. J. Articles by Scaravilli, F. Related Collections Behavioral Changes and Stroke Other Stroke Treatment - Medical Other Vascular biology

(Stroke. 1999;30:687-689.)
© 1999 American Heart Association, Inc.

Case Report

Spatz-Lindenberg Disease

A Rare Cause of Vascular Dementia

A. J. Larner, MD; Desmond Kidd, MD; Paul Elkington, MRCP(UK); Peter Rudge, FRCP Francesco Scaravilli, FRCPath

From the National Hospital for Neurology and Neurosurgery, London, UK.

Correspondence to Dr A.J. Larner, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG UK

Background—Isolated cerebral thromboangiitis obliterans (Spatz-Lindenberg disease) is not well recognized as a cause of vascular dementia.

Case Description—A 58-year-old woman presented with dementia and pyramidal signs. Neuroimaging showed multiple areas of white matter change. Brain biopsy showed intimal thickening of the walls of leptomeningeal and intraparenchymal arteries, almost to complete occlusion, with an intact internal elastic lamina and media and without inflammation or infiltration. The cortex showed only moderate gliosis.

Conclusions—Spatz-Lindenberg disease should be considered in the differential diagnosis of vascular dementia. Additional studies of its pathogenesis are required to determine appropriate treatment.

Key Words: dementia • Spatz-Lindenberg disease • thromboangiitis obliterans • vasculopathy

This article has been cited by other articles:

				J. D. Warren, J. M. Schott, N. C. Fox, M. Thom, T. Revesz, J. L. Holton, F. Scaravilli, D. G. T. Thomas, G. T. Plant, P. Rudge, et al. Brain biopsy in dementia Brain, September 1, 2005; 128(9): 2016 - 2025. [Abstract] [Full Text] [PDF]