(Stroke. 2000;31:33.)
© 2000 American Heart Association, Inc.
Original Contributions |
Low Plasma Antioxidant Activity Is Associated With High Lesion Volume and Neurological Impairment in Stroke
From the Departments of Clinical Chemistry (J.S.L.), Neurology and Rehabilitation (J.-P.A., M.J., G.M.), Neurosurgery (K.L.), and Diagnostic Radiology (P.D.), Tampere University Hospital; Research Unit of Alcohol Diseases, University of Helsinki (H.A.); and the Department of Mental Health and Alcohol Research (H.A.), National Public Health Institute, Helsinki, Finland.
Correspondence to Hannu Alho, MD, PhD, National Public Health Institute, Department of Mental Health and Alcohol Research, PO Box 719, 00101 Helsinki, Finland. E-mail hannu.alho{at}ktl.fi
Background and Purpose—Oxidative stress is probably involved in neuronal damage induced by ischemia-reperfusion. The purpose of this study was to assess the role of antioxidant activity in cerebral ischemic stroke.
Methods—Antioxidant activity of blood plasma and cerebrospinal fluid was assessed in 22 patients with cerebral hemisphere infarction that was verified and quantified by MRI.
Results—Low total peroxyl radical trapping potential of plasma,
but not of cerebrospinal fluid, was associated with high lesion volume
and high neurological impairment assessed by scores on NIH Stroke
Scale, Barthel Index, and Hand Motor Score tests. The plasma
concentrations of ascorbic acid, 
-tocopherol, and
protein thiols were also associated with the degree of neurological
impairment.
Conclusions—These data suggest that the antioxidant activity of plasma may be an important factor providing protection from neurological damage caused by stroke-associated oxidative stress.
Key Words: antioxidants • cerebral infarction • cerebral ischemia • reperfusion • stroke
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