(Stroke. 2000;31:392.)
© 2000 American Heart Association, Inc.
Original Contributions |
Risk Factors for Multiple Intracranial Aneurysms
From the Department of Neurosurgery, Helsinki University Central Hospital (Finland).
Background and Purpose—The presence of multiple intracranial aneurysms may be a sign of significant risk factors for aneurysm formation that differ from those factors that increase risk for aneurysm rupture. Only 2 studies concern independent risk factors for multiple aneurysms, and the results are in part controversial. This study was designed to identify independent risk factors for multiple intracranial aneurysms in patients with subarachnoid hemorrhage.
Methods—Of 266 patients with aneurysmal subarachnoid hemorrhage (139 men and 127 women, aged 15 to 60 years), 80 (30%) had multiple intracranial aneurysms. The prevalence of several health-related habits, previous diseases, and medications of these patients were compared by multiple logistic regression between those with single and those with multiple aneurysms.
Results—On the basis of multivariate statistics, only regular cigarette smoking at any time was a significant risk factor for the presence of multiple aneurysms. The odds ratio (OR) of smoking for multiple aneurysms was 2.10 (95% CI, 1.06 to 4.13) after adjustment for age and sex. After additional adjustment for hypertension, the risk was 2.06 (95% CI, 1.04 to 4.07). Of other variables, only age (OR, 1.02 per year; 95% CI, 1.00 to 1.05; P=0.09) and female sex (OR, 1.60; 95% CI, 0.90 to 2.85; P=0.11) showed a tendency to increase the risk for multiple aneurysms after adjustment for smoking. On the other hand, patients with hypertension had significantly (P=0.029) more aneurysms (1.61±1.04) than did those without (1.37±0.68), although they did not more frequently have multiple aneurysms.
Conclusions—Cigarette smoking and possibly also age and female sex seem to be risk factors for multiple intracranial aneurysms in patients of working age who have suffered a subarachnoid hemorrhage. Patients with hypertension seem to have more aneurysms than those without.
Key Words: cerebral aneurysm • cigarette smoking • hypertension • sex • subarachnoid hemorrhage
This article has been cited by other articles:
 |
|
 |
|
  S.W. Hetts, J. Narvid, N. Sanai, M.T. Lawton, N. Gupta, H.J. Fullerton, C.F. Dowd, R.T. Higashida, and V.V. Halbach Intracranial Aneurysms in Childhood: 27-Year Single-Institution Experience AJNR Am. J. Neuroradiol., August 1, 2009; 30(7): 1315 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Bederson, E. S. Connolly Jr, H. H. Batjer, R. G. Dacey, J. E. Dion, M. N. Diringer, J. E. Duldner Jr, R. E. Harbaugh, A. B. Patel, and R. H. Rosenwasser Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association Stroke, March 1, 2009; 40(3): 994 - 1025. [Full Text] [PDF]
|
|
|
|
|
|
W.J. van Rooij, M.E. Sprengers, A.N. de Gast, J.P.P. Peluso, and M. Sluzewski 3D Rotational Angiography: The New Gold Standard in the Detection of Additional Intracranial Aneurysms AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 976 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kurth, S. C. Moore, J. M. Gaziano, C. S. Kase, M. J. Stampfer, K. Berger, and J. E. Buring Healthy lifestyle and the risk of stroke in women. Arch Intern Med, July 10, 2006; 166(13): 1403 - 1409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Feigin and M. Findlay Advances in Subarachnoid Hemorrhage Stroke, February 1, 2006; 37(2): 305 - 308. [Full Text] [PDF]
|
|
|
|
|
|
M. J.H. Wermer, P. Greebe, A. Algra, and G. J.E. Rinkel Incidence of Recurrent Subarachnoid Hemorrhage After Clipping for Ruptured Intracranial Aneurysms Stroke, November 1, 2005; 36(11): 2394 - 2399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Feigin, V. Parag, C. M. M. Lawes, A. Rodgers, I. Suh, M. Woodward, K. Jamrozik, H. Ueshima, and on behalf of the Asia Pacific Cohort Studies Colla Smoking and Elevated Blood Pressure Are the Most Important Risk Factors for Subarachnoid Hemorrhage in the Asia-Pacific Region: An Overview of 26 Cohorts Involving 306 620 Participants Stroke, July 1, 2005; 36(7): 1360 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.M. Ruigrok, G.J.E. Rinkel, A. Algra, T.W.M. Raaymakers, and J. van Gijn Characteristics of intracranial aneurysms in patients with familial subarachnoid hemorrhage Neurology, March 23, 2004; 62(6): 891 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Anderson, V. Feigin, D. Bennett, R.-B. Lin, G. Hankey, K. Jamrozik, and for the Australasian Cooperative Research on Subar Active and Passive Smoking and the Risk of Subarachnoid Hemorrhage: An International Population-Based Case-Control Study Stroke, March 1, 2004; 35(3): 633 - 637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kurth, C. S. Kase, K. Berger, J. M. Gaziano, N. R. Cook, and J. E. Buring Smoking and Risk of Hemorrhagic Stroke in Women Stroke, December 1, 2003; 34(12): 2792 - 2795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ballard, K. T. Kreiter, J. Claassen, R. G. Kowalski, E. S. Connolly, and S. A. Mayer Risk Factors for Continued Cigarette Use After Subarachnoid Hemorrhage Stroke, August 1, 2003; 34(8): 1859 - 1863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Juvela, D. Gaist, S. Bak, S. P. Johnsen, L. Pedersen, H. T. Sorensen, S. Friis, J. H. Olsen, W. J. Blot, and J. K. McLaughlin Nonsteroidal Anti-Inflammatory Drugs as Risk Factors for Spontaneous Intracerebral Hemorrhage and Aneurysmal Subarachnoid Hemorrhage * Response Stroke, June 1, 2003; 34 (6): e34 - e36. [Full Text] [PDF]
|
|
|
|
|
|
T. Kurth, C. S. Kase, K. Berger, E. S. Schaeffner, J. E. Buring, and J. M. Gaziano Smoking and the Risk of Hemorrhagic Stroke in Men Stroke, May 1, 2003; 34(5): 1151 - 1155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kaminogo, M. Yonekura, and S. Shibata Incidence and Outcome of Multiple Intracranial Aneurysms in a Defined Population Stroke, January 1, 2003; 34(1): 16 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Grond-Ginsbach, H. Schnippering, I. Hausser, R. Weber, I. Werner, H. H. Steiner, N. Luttgen, O. Busse, A. Grau, and T. Brandt Ultrastructural Connective Tissue Aberrations in Patients With Intracranial Aneurysms Stroke, September 1, 2002; 33(9): 2192 - 2196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Juvela, K. Poussa, and M. Porras Factors Affecting Formation and Growth of Intracranial Aneurysms : A Long-Term Follow-Up Study Stroke, February 1, 2001; 32(2): 485 - 491. [Abstract] [Full Text] [PDF]
|
|