(Stroke. 2000;31:1958.)
© 2000 American Heart Association, Inc.
Original Contributions |
Cerebral Blood Flow and Blood Volume Measured by Magnetic Resonance Imaging Bolus Tracking After Acute Stroke in Pigs
Comparison With [15O]H2O Positron Emission Tomography
From the PET-Center (M.S., A.G.) and the Department of Neuroradiology (L.R., C.G., L.Ø.), Aarhus University Hospital, Aarhus, Denmark; and the Department of Neurological Surgery (M.S.), Ehime University School of Medicine, Ehime, Japan.
Correspondence and reprint requests to Dr Masaharu Sakoh, MD, PhD, Department of Neurological Surgery, Ehime University School of Medicine, Shizukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan. E-mail sakoh{at}m.ehime-u.ac.jp
Background and Purpose—Early and accurate assessments of cerebral ischemia allow therapy to be tailored to individual stroke patients. We examined the feasibility of using a novel method for measuring cerebral blood flow (CBF) of ischemic tissue based on MRI after middle cerebral artery occlusion (MCAO). Moreover, the regional correlations between CBF and cerebral blood volume (CBV) were investigated in the regions with acute ischemic stroke.
Methods—CBF and CBV were measured before and after MCAO or reperfusion by positron emission tomography (PET) in 13 pigs. Just after the PET scans, CBF and CBV were measured by MR bolus tracking and were compared with results obtained by PET at 6 hours after permanent MCAO or reperfusion. The infarction was verified histologically.
Results—The MR method yielded parametric CBF and CBV maps with tissue contrast in good agreement with parametric PET images, which demonstrated hypoperfused and hyperperfused areas after MCAO or reperfusion. Both MRI and PET technology showed that CBF values below 60% of the contralateral value induced a reduction of CBV, which committed the tissue to infarction.
Conclusions—The novel MR method provides accurate measurement of CBF and CBV in acute stroke and hence gives useful information for planning the appropriate therapeutic intervention.
Editorial Comment
Comparison With [15O]H2O Positron Emission Tomography
Center for Stroke Research, Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan {hd1}
This article has been cited by other articles:
 |
|
 |
|
  O. Zaro-Weber, W. Moeller-Hartmann, W.-D. Heiss, and J. Sobesky The Performance of MRI-Based Cerebral Blood Flow Measurements in Acute and Subacute Stroke Compared With 15O-Water Positron Emission Tomography: Identification of Penumbral Flow Stroke, July 1, 2009; 40(7): 2413 - 2421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.D. Murphy, X. Chen, and T.-Y. Lee Serial Changes in CT Cerebral Blood Volume and Flow after 4 Hours of Middle Cerebral Occlusion in an Animal Model of Embolic Cerebral Ischemia AJNR Am. J. Neuroradiol., April 1, 2007; 28(4): 743 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Honda, H. Imai, M. Ishikawa, C. Kubota, T. Shimizu, M. Fukunaga, and N. Saito Cilostazol Attenuates Gray and White Matter Damage in a Rodent Model of Focal Cerebral Ischemia Stroke, January 1, 2006; 37(1): 223 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wintermark, M. Sesay, E. Barbier, K. Borbely, W. P. Dillon, J. D. Eastwood, T. C. Glenn, C. B. Grandin, S. Pedraza, J.-F. Soustiel, et al. Comparative Overview of Brain Perfusion Imaging Techniques Stroke, September 1, 2005; 36(9): e83 - e99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.F. Soustiel, T.C. Glenn, P. Vespa, B. Rinsky, C. Hanuscin, and N.A. Martin Assessment of Cerebral Blood Flow by Means of Blood-Flow-Volume Measurement in the Internal Carotid Artery: Comparative Study With a 133Xenon Clearance Technique Stroke, August 1, 2003; 34(8): 1876 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. de Crespigny Editorial Comment--Mismatch or Misconception? Stroke, July 1, 2003; 34(7): 1683 - 1685. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sakoh and A. Gjedde Neuroprotection in hypothermia linked to redistribution of oxygen in brain Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H17 - H25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mukherjee, H. C. Kang, T. O. Videen, R. C. McKinstry, W. J. Powers, and C. P. Derdeyn Measurement of Cerebral Blood Flow in Chronic Carotid Occlusive Disease: Comparison of Dynamic Susceptibility Contrast Perfusion MR Imaging with Positron Emission Tomography AJNR Am. J. Neuroradiol., May 1, 2003; 24(5): 862 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Latchaw, H. Yonas, G. J. Hunter, W. T.C. Yuh, T. Ueda, A. G. Sorensen, J. L. Sunshine, J. Biller, L. Wechsler, R. Higashida, et al. Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia: A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, From the Council on Cardiovascular Radiology of the American Heart Association Stroke, April 1, 2003; 34(4): 1084 - 1104. [Full Text] [PDF]
|
|
|
|
|
|
C. Schaller, J. Schramm, D. Haun, and B. Meyer Patterns of Cortical Oxygen Saturation Changes During CO2 Reactivity Testing in the Vicinity of Cerebral Arteriovenous Malformations Stroke, April 1, 2003; 34(4): 938 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.R. Rutgers, M.J.P. van Osch, L.J. Kappelle, W.P.T.M. Mali, and J. van der Grond Cerebral Hemodynamics and Metabolism in Patients With Symptomatic Occlusion of the Internal Carotid Artery Stroke, March 1, 2003; 34(3): 648 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fiehler, M. von Bezold, T. Kucinski, R. Knab, B. Eckert, O. Wittkugel, H. Zeumer, and J. Rother Cerebral Blood Flow Predicts Lesion Growth in Acute Stroke Patients Stroke, October 1, 2002; 33(10): 2421 - 2425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sugawara, T. Ueda, T. Kikuchi, N. Yamamoto, Y. Semba, S. Nakata, T. Mochizuki, and J. Ikezoe Hyperactivity of 99mTc-HMPAO Within 6 Hours in Patients with Acute Ischemic Stroke J. Nucl. Med., September 1, 2001; 42(9): 1297 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rohl, L. Ostergaard, C. Z. Simonsen, P. Vestergaard-Poulsen, G. Andersen, M. Sakoh, D. Le Bihan, and C. Gyldensted Viability Thresholds of Ischemic Penumbra of Hyperacute Stroke Defined by Perfusion-Weighted MRI and Apparent Diffusion Coefficient Stroke, May 1, 2001; 32(5): 1140 - 1146. [Abstract] [Full Text] [PDF]
|
|