(Stroke. 2001;32:107.)
© 2001 American Heart Association, Inc.
Original Contributions |
Effect of Lesion Location on Upper Limb Motor Recovery After Stroke
From the University of Oklahoma Health Science Center, Oklahoma City (F.d.N.A.P.S.); and The Weill Medical College of Cornell University at The Burke Rehabilitation Hospital, White Plains, NY (M.J.R.).
Correspondence to Fátima de N.A.P. Shelton, MD, OUHSC Department of Neurology, 711 Stanton L. Young Blvd, Suite 209, Oklahoma City, OK 73104. E-mail fshelton{at}dnamail.com
Background and Purpose—The purpose of this study was to assess the effects of stroke involvement of primary and secondary hemispheric motor systems and corticofugal tracts on arm and hand recovery.
Methods—Forty-one
patients participating in an inpatient stroke rehabilitation database,
admitted 17±2 (SEM) days after initial unilateral hemispheric
ischemic stroke, with neuroimaging studies performed >48 hours
after stroke and with minimal upper limb (UL) movement (admission
Fugl-Meyer UL motor scores 
9; normal score, 58) were studied.
Patients were divided into 3 groups according to their UL discharge
Fugl-Meyer score: 0 to 9, no/poor recovery; 10 to 18, well-defined
flexion-extension synergies; and >18, synergies+isolated movements.
Lesions affecting the following structures were recorded: primary
motor cortex, premotor area, supplementary motor area, anterior half of
the middle third of corona radiata (secondary motor efferents),
posterior half of the middle third of corona radiata (primary motor
efferents), genu, anterior and posterior limbs of the internal capsule
(PLIC), basal ganglia, and thalamus. 
2
Analysis and ANOVA were used to study the significance of
stroke location on UL motor recovery.
Results—The effect of involvement of primary, premotor, or supplementary motor areas on motor recovery did not reach statistical significance. Patients with purely cortical stroke were likely to recover UL isolated movement (3 of 4) compared with purely subcortical (1 of 17) or mixed cortical-subcortical stroke location (2 of 20) (P=0.009). Of those with cortical, subcortical, or mixed cortical plus subcortical lesions sparing the PLIC, 5 of 13 recovered isolated UL movement (P=0.01). Only 1 of 28 patients with involvement of the PLIC plus adjacent corona radiata, basal ganglia, or thalamus recovered isolated UL movement (P=0.01). Patients with small lacunar strokes affecting only the PLIC did not have sufficient motor deficits 2 weeks after stroke to meet inclusion criteria.
Conclusions—The probability of recovery of isolated UL movement decreases progressively with lesion location as follows: cortex, corona radiata, and PLIC. This is consistent with our current understanding of redundant cortical motor representation and convergence of corticofugal motor efferents as they pass through the corona radiata to the PLIC.
Key Words: hemiplegia • prognosis • rehabilitation • stroke outcome
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