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(Stroke. 2001;32:2939.)
© 2001 American Heart Association, Inc.

Research Report

Feasibility of an Affected Sibling Pair Study in Ischemic Stroke

Results of a 2-Center Family History Registry

James F. Meschia, MD; Robert D. Brown, Jr, MD; Thomas G. Brott, MD; John Hardy, PhD; Elizabeth J. Atkinson, MS Peter C. O’Brien, PhD

From the Department of Neurology (J.F.M., T.G.B.) and Section of Pharmacology (J.H.), Mayo Clinic, Jacksonville, Fla, and the Department of Neurology (R.D.B.) and Section of Biostatistics (E.J.A., P.C.O’B.), Mayo Clinic, Rochester, Minn.

Reprint requests to James F. Meschia, MD, Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224.

Abstract

Background and Purpose— We sought to determine pedigree availability for a concordant sibling pair study of genetic risk factors in ischemic stroke.

Methods— Probands with confirmed ischemic stroke were prospectively enrolled. Family histories were obtained by systematic interview. A study neurologist prospectively assigned stroke subtype.

Results— Of 310 probands (median age, 75 years; range, 26 to 97 years; 48% women), 75% had at least 1 living sibling; 10%, at least 1 concordant living sibling; 2%, at least 1 concordant sibling living in the same city; and 7%, at least 1 concordant living and 1 discordant living sibling. Likelihood of having a concordant sibling increased significantly with proband age, even after adjustment for sibship size (P=0.002). Positive family history of stroke was not related to either proband stroke subtype or risk factor profile.

Conclusions— Approximately 10 probands were screened to find 1 potentially concordant living sibling. A concordant sibling pair study should be multicentered and enable enrollment of siblings from diverse geographic areas.

Key Words: cerebral infarction • feasibility studies • pedigree research • risk factors, genetic • stroke classification • stroke, ischemic

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