(Stroke. 2001;32:1181.)
© 2001 American Heart Association, Inc.
Original Contributions |
Association of Apolipoprotein E Polymorphism With Outcome After Aneurysmal Subarachnoid Hemorrhage
A Preliminary Study
From the Department of Neurosurgery, Helsinki University Central Hospital (T.N., J.Ö., M.N.), Helsinki, Finland; the Department of Forensic Medicine, University of Tampere and Tampere University Hospital (T.N., E.I., T.A.K., P.J.K.), Tampere, Finland; and the Department of Clinical Pathology and Forensic Medicine (P.J.K.), University of Kuopio, Kuopio, Finland.
Correspondence to Tero Niskakangas, Helsinki University Central Hospital, Department of Neurosurgery, Topeliuksenkatu 5, FIN- 00260 Helsinki, Finland. E-mail tero.niskakangas{at}hus.fi
Background and Purpose—Variation in the outcome after aneurysmal subarachnoid hemorrhage (SAH) is not fully explained by known prognostic factors. APOE genotype is the most important genetic determinant of susceptibility to Alzheimer’s disease, and it is also shown to be associated with the outcome after traumatic brain injury. We studied the association of apolipoprotein E polymorphism with the outcome after aneurysmal SAH.
Methods—A total of 160 consecutive patients were admitted after SAH to a neurosurgical unit. The clinical assessment after the SAH was performed with the Hunt and Hess grading scale. The severity of the bleeding as visualized on CT was assessed by Fisher’s grading system. Outcome was assessed with the Glasgow Outcome Scale. APOE genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism.
Results—126 patients
had aneurysmatic SAH, and detailed information on outcome and
APOE genotype was
available for 108 patients (86%). Sixteen (40%) of 40 patients with
APOE 
4 had an unfavorable
outcome compared with 13 (19%) of 68 without the
APOE 4 allele (OR 2.8,
95% CI 1.18 to 6.77). Association was more significant after
adjustment for age, rebleeding, clinical status on admission, and CT
scan findings (OR 7.1, 95% CI 1.9 to 26.3;
P=0.0035).
Conclusions—Our findings show a significant genetic association of APOE polymorphism with outcome after spontaneous aneurysmal SAH. Genetic factors thus seem to explain a part of individual differences in the recovery of SAH.
Key Words: apolipoproteins • genetics • outcome • subarachnoid hemorrhage
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