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(Stroke. 2002;33:626.)
© 2002 American Heart Association, Inc.

Short Communications

High Rate of Recanalization of Middle Cerebral Artery Occlusion During 2-MHz Transcranial Color-Coded Doppler Continuous Monitoring Without Thrombolytic Drug

Pascal Cintas, MD; Anne Pavy Le Traon, MD, PhD Vincent Larrue, MD

From the Department of Neurology, University of Toulouse (France).

Correspondence to Professor Vincent Larrue, Service de neurologie, Hopital de Rangueil, 1 avenue Jean Poulhes, 31403 Toulouse, France. E-mail larrue.v{at}chu-toulouse.fr

Abstract

Background and Purpose— Experimental evidence indicates that ultrasound can accelerate thrombolysis. We report our findings on early recanalization during transcranial color-coded Doppler (TCCD) continuous monitoring in acute stroke patients with middle cerebral artery (MCA) main stem occlusion.

Methods— We performed continuous TCCD monitorings in 6 consecutive patients with acute MCA main stem occlusion using a 2-MHz transducer. Patients were not treated with recombinant tissue plasminogen activator.

Results— Partial recanalization, defined as blunted waveforms, occurred during monitoring in 5 patients (83%). The mean time to beginning of recanalization was 17.2±9.6 minutes. Complete recanalization at 24 hours occurred in only 1 patient. The mean National Institutes of Health Stroke Scale score in the patients who recanalized during monitoring was 21.2±4.1 at baseline, 19.2±5 at 2 hours, and 15.6±3.4 at 24 hours (P=0.1).

Conclusions— In this short series of patients with acute MCA main stem occlusion, not treated with recombinant tissue plasminogen activator, we found a high rate of early partial recanalization during continuous exposure to 2-MHz ultrasound.

Key Words: middle cerebral artery • thrombolysis • ultrasonography, Doppler, transcranial

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