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(Stroke. 2002;33:1120.)
© 2002 American Heart Association, Inc.

Original Contributions

Cellular Responses of Bioabsorbable Polymeric Material and Guglielmi Detachable Coil in Experimental Aneurysms

Yuichi Murayama, MD; Fernando Viñuela, MD; Satoshi Tateshima, MD; Nestor R. Gonzalez, MD; Joon K. Song, MD; Haleh Mahdavieh, BS Luisa Iruela-Arispe, PhD

From the Division of Interventional Neuroradiology (Y.M., F.V., S.T., N.R.G., J.K.S.) and Leo G. Rigler Radiological Research Center, and Department of Molecular Cell and Developmental Biology (H.M., L.I-A.), Molecular Biology Institute, University of California at Los Angeles.

Correspondence to Yuichi Murayama, MD, Division of Interventional Neuroradiology, Department of Radiological Sciences, UCLA School of Medicine and Medical Center, 10833 Le Conte Ave, Los Angeles, CA 90095. E-mail ymurayama{at}mednet.ucla.edu

Background and Purpose— Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms.

Methods— Four different concentrations of lactide/glycolic acid copolymer [poly(D-L-lactic-co-glycolic acid)] (PLGA), 85/15, 75/25, 65/35, and 50/50, were used as BPMs. Sixteen experimental aneurysms were created in 8 swine. Eight-millimeter-long spiral-shaped BPMs were surgically implanted in the aneurysms without tight packing (n=3 for each BPM). Guglielmi detachable coils (GDCs) were used as control (n=4). The animals were killed 14 days after embolization, and angiographic, histological, and immunohistochemical analyses were performed.

Results— Despite loose packing of aneurysms with BPMs, faster BPMs such as 50/50 or 65/35 PLGA demonstrated more mature collagen formation and fibrosis in the sac and neck of the aneurysm. One aneurysm treated with 65/35 PLGA, 1 treated with 75/25 PLGA, and all 3 treated with 85/15 PLGA showed a neck remnant on angiography. There was a linear relationship between collagen levels and polymer degradation properties (r=-0.9513).

Conclusions— This preliminary animal study indicates that acceleration of aneurysm healing with the use of BPM is feasible. This concept can be applied to decrease and perhaps prevent aneurysmal recanalization after endovascular treatment of cerebral aneurysms.

Key Words: animal models • endovascular therapy • intracranial aneurysm • polymers • tissue engineering

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