This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Meraviglia, M. V. Articles by Minicucci, F. Search for Related Content PubMed PubMed Citation Articles by Meraviglia, M. V. Articles by Minicucci, F. Related Collections Carotid Stenosis Doppler ultrasound, Transcranial Doppler etc. Carotid endarterectomy Lipid and lipoprotein metabolism Mechanism of atherosclerosis/growth factors

(Stroke. 2002;33:1139.)
© 2002 American Heart Association, Inc.

Short Communications

Autoantibodies Against Oxidatively Modified Lipoproteins and Progression of Carotid Restenosis After Carotid Endarterectomy

Maria Vittoria Meraviglia, MD; Elena Maggi, MD; Giorgio Bellomo, MD; Marco Cursi, BME; Giovanna Fanelli, MD Fabio Minicucci, MD

From Servizio di Neurofisiologia, Ospedale San Raffaele, Milan (M.V.M., M.C., G.F., F.M.); Servizio di Pronto Soccorso e Accettazione, Ospedale Policlinico San Matteo, Pavia (E.M.); and Ospedale Maggiore, Novara (G.B.), Italy.

Reprint request to Fabio Minicucci, MD, Servizio di Neurofisiologia, Ospedale San Raffaele, Via Olgettina, 60, 20132 Milano, Italy. E-mail minicucci.fabio{at}hsr.it

Abstract

Background— The purpose of this study was to determine whether LDL oxidation could play an important pathogenic role in early restenosis after carotid endarterectomy. An immunologic and biochemical study was performed on a group of patients who underwent carotid endarterectomy, and the degree of intima-media thickness was measured 6 months after surgery.

Summary of Report— Fifty-two consecutive patients were included in the study. The presence of antibodies against oxidized LDL in the serum at the time of surgery was evaluated and compared with echo Doppler flow imaging 6 months after the operation. A statistically significant correlation was found between the arterial wall thickness at the site of surgery and the absolute value of IgG antibodies against oxidized LDL (P<0.012) and IgM immunocomplexes (P<0.043).

Conclusions— The presence of antibodies against oxidized LDL at the time of surgery seems to predict a greater intima-media wall hyperplasia at 6 months after surgery, usually recognized as early restenosis.

Key Words: carotid endarterectomy • carotid stenosis • lipoproteins, LDL • oxidative stress

This article has been cited by other articles:

				D. Feinbloom and K. A. Bauer Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2043 - 2053. [Abstract] [Full Text] [PDF]