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(Stroke. 2002;33:896.)
© 2002 American Heart Association, Inc.

Original Contributions

No Association of Paraoxonase Genotype or Atherosclerosis With Cerebral Amyloid Angiopathy

M. Yamada, MD, PhD; N. Sodeyama, MD, PhD; Y. Itoh, MD, PhD; E. Otomo, MD, PhD; M. Matsushita, MD, PhD H. Mizusawa, MD, PhD

From the Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan (M.Y.); Department of Neurology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan (N.S., H.M.); Departments of Internal Medicine (Y.I., E.O.) and Pathology (Y.I.), Yokufukai Geriatric Hospital, Tokyo, Japan; and Department of Neuropathology, Tokyo Institute of Psychiatry, Tokyo, Japan (M.M.).

Correspondence to Prof Masahito Yamada, Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1, Takara-Machi, Kanazawa 920-8640, Japan. E-mail m-yamada{at}med.kanazawa-u.ac.jp

Background and Purpose— Both cerebral amyloid angiopathy (CAA) and paraoxonase have been reported to be related to lipid metabolism and atherosclerosis. We investigated whether the paraoxonase gene (PON1) polymorphism and atherosclerosis are associated with risk of CAA.

Methods— Associations of the PON1 polymorphism and atherosclerosis of the aorta and coronary and cerebral arteries with the severity of CAA were investigated in 154 elderly Japanese individuals, including 47 patients with Alzheimer’s disease.

Results— The PON1 polymorphism or severity of atherosclerosis of the arteries was not associated with the severity of CAA.

Conclusions— The PON1 polymorphism and atherosclerosis would not appear to be associated with risk of CAA in the elderly, although further study with larger samples is necessary for confirmation.

Key Words: Alzheimer disease • amyloid • atherosclerosis • cerebrovascular disorders • polymorphism (genetics)

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