doi: 10.1161/hs0402.105245
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(Stroke. 2002;33:907.)
© 2002 American Heart Association, Inc.
Original Contributions |
Alcohol Consumption and Risk of Ischemic Stroke
The Framingham Study
From the Section of Preventive Medicine and Epidemiology, Boston University School of Medicine (L.D., R.C.E, P.A.W.); Department of Epidemiology and Biostatistics, Boston University School of Public Health (A.B., A.S.); and Department of Mathematics, Boston University (R.B.D’A.), Boston, Mass.
Correspondence to Luc Djoussé, MD, MPH, Boston University School of Medicine, 715 Albany St, Room B-612, Boston, MA 02118. E-mail ldjousse{at}bu.edu
Background and Purpose— Stroke is a major cause of death in the United States. The association between alcohol consumption and ischemic stroke (IS) remains controversial.
Methods— We used data collected on participants in the Framingham Study to assess the association between total alcohol intake and type of alcoholic beverage and development of IS, overall and according to age.
Results— A total of 196 men and 245 women developed IS during three 10-year follow-up periods. In the categories of never drinkers, drinkers of 0.1 to 11, 12 to 23, and 
24 g/d of ethanol (a "typical drink" is 
12 g of ethanol), and former drinkers of 0.1 to 11 and 12 g/d, crude incidence rates of IS were 6.5, 5.9, 4.9, 5.0, 6.7, and 17.8 cases per 1000 person-years, respectively, for men and 5.9, 4.1, 4.1, 4.3, 8.3, and 7.1, respectively, for women. Overall, compared with never drinkers in a multivariate Cox regression, current alcohol consumption was not related significantly to IS in either sex. Former drinking of 12 g/d of alcohol was associated with a 2.4 times higher risk of IS among men but not among women. When stratified by age, alcohol intake was associated with lower risk of IS among subjects aged 60 to 69 years. In beverage-specific analysis, only wine consumption was related to a decreased risk of IS.
Conclusions— Our data showed no significant association between total alcohol and IS overall but showed a protective effect of alcohol among subjects aged 60 to 69 years.
Key Words: alcohol drinking • beer • cerebrovascular accident • stroke, ischemic • wine
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