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(Stroke. 2003;34:2830.)
© 2003 American Heart Association, Inc.

Original Contributions

Determination of Etiologic Mechanisms of Strokes Secondary to Coronary Artery Bypass Graft Surgery

Donald S. Likosky, PhD; Charles A.S. Marrin, MB, BS; Louis R. Caplan, MD; Yvon R. Baribeau, MD; Jeremy R. Morton, MD; Ronald M. Weintraub, MD; Gregg S. Hartman, MD; Felix Hernandez, Jr, MD; Steven P. Braff, MD; David C. Charlesworth, MD; David J. Malenka, MD; Cathy S. Ross, MS Gerald T. O’Connor, PhD for the Northern New England Cardiovascular Disease Study Group

From the Departments of Medicine (D.S.L., C.A.S.M., D.J.M., C.S.R., G.T.O.), Surgery (C.A.S.M.), Anesthesiology (G.S.H.), and Community and Family Medicine (D.S.L., D.J.M., C.S.R., G.T.O.), Dartmouth-Hitchcock Medical Center, Hanover, NH; Departments of Neurology (L.R.C.) and Surgery (R.M.W.), Beth Israel Deaconess Medical Center, Boston, Mass; Department of Surgery, Catholic Medical Center, Manchester, NH (Y.R.B., D.C.C.); Department of Surgery, Maine Medical Center, Portland (J.R.M.); Department of Surgery, Eastern Maine Medical Center, Bangor (F.H.); and Department of Radiology, Fletcher Allen Health Care, Burlington, Vt (S.P.B.).

Reprint requests to Donald S. Likosky, PhD, Clinical Research Section, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756. E-mail Donald.Likosky{at}Dartmouth.edu

Background and Purpose— Current research focused on stroke in the setting of coronary artery bypass graft (CABG) surgery has missed important opportunities for additional understanding by failing to consider the range of different stroke mechanisms. We developed and implemented a classification system to identify the distribution and timing of stroke subtypes.

Methods— We conducted a regional study of 388 patients with the diagnosis of stroke after isolated CABG surgery in northern New England from 1992 to 2000. Data were collected on patient and disease characteristics, intraoperative and postoperative care, and outcomes. Stroke etiology was classified into 1 of the following: hemorrhage, thromboembolic (embolic, thrombotic, lacunar), hypoperfusion, other (subtype not listed above), multiple (2 competing mechanisms), or unclassified (unknown mechanism). The reliability of the classification system was determined by percent agreement and statistics.

Results— Embolic strokes accounted for 62.1% of strokes, followed by multiple etiologies (10.1%), hypoperfusion (8.8%), lacunar (3.1%), thrombotic (1.0%), and hemorrhage (1.0%). There were 54 strokes with unknown etiology (13.9%). There were no strokes classified as "other." Nearly 45% (105/235) of the embolic and 56% (18/32) of hypoperfusion strokes occurred within the first postoperative day.

Conclusions— We used a locally developed classification system to determine the etiologic mechanism of 388 strokes secondary to CABG surgery. The principal etiologic mechanism was embolic, followed by stroke having multiple mechanisms and hypoperfusion. Regardless of mechanism, strokes predominantly occurred within the first postoperative day.

Key Words: cerebral infarction • coronary artery bypass • embolism

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