Published online before print January 23, 2003, doi: 10.1161/01.STR.0000053851.17964.C6
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(Stroke. 2003;34:422.)
© 2003 American Heart Association, Inc.
Original Contributions |
Family History and Risk of Subarachnoid Hemorrhage
A Case-Control Study in Nagoya, Japan
From the Department of Public Health (K.O.), Aichi Prefectural College of Nursing and Health, Nagoya; the Department of Preventive Medicine/Biostatistics and Medical Decision Making (R.H., Y.O.), Nagoya University Graduate School of Medicine, Nagoya; Kyoto University Health Center (T.K.), Kyoto; Daini Red Cross Hospital (A.A., M.O.), Nagoya; and Nagoya City Higashi Municipal Hospital (T.T.), Nagoya, Japan.
Correspondence to Kazushi Okamoto, MD, Aichi Prefectural College of Nursing and Health, Tougoku, Kamishidami, Moriyama-ku, Nagoya, 463-8502, Japan. E-mail okamoto{at}aichi-nurs.ac.jp
Background and Purpose— We sought to examine the relation between a family history of subarachnoid hemorrhage (SAH) and the risk of SAH by using a case-control study.
Methods— Case subjects consisted of a consecutive series of 195 patients with spontaneous SAH, aged 30 to79 years, with aneurysms confirmed by angiography and/or CT scan. Hospital and community control subjects were identified and matched to each case by sex and age (±2 years). Multiple conditional logistic regression was used to calculate the odds ratio (OR) and 95% interval (CI) adjusted for potential confounders.
Results— Having a family member with SAH was significantly associated with an increased risk of SAH (OR, 4.0, 95% CI, 2.0 to 8.0), after adjusting for potential confounders. The risk for a positive family history of SAH was similar for men and women and was inversely related to the SAH patient’s age. A maternal positive SAH history (OR, 5.4; 95% CI, 1.8 to 16.0) posed a much greater risk than a paternal positive history (OR, 3.2, 95% CI, 1.1 to 13.4).
Conclusions— A positive family history of SAH was significantly and strongly associated with the risk of SAH. To prevent the onset of SAH at a younger age, much more attention should be given to individuals with any family member (first-degree relatives) suffering SAH episodes.
Key Words: case-control studies • family history • subarachnoid hemorrhage
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