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(Stroke. 2003;34:1035.)
© 2003 American Heart Association, Inc.

Research Reports

Feasibility of Radioactive Embolization of Intracranial Aneurysms Using ³²P-Implanted Coils

Jean Raymond, MD; Philippe Leblanc, PhD; Anick Lambert, MSc; Stavros A. Georganos, MD; François Guilbert, MD; Christian Janicki, PhD Sjoerd Roorda, PhD

From the Department of Radiology (J.R., S.A.G., F.G.) and Research Centre (J.R., P.L., A.L.) of Centre Hospitalier de l’Université de Montréal; Department of Medical Physics (C. J.), McGill University Health Centre; and Physics Department (S.R.), Université de Montréal, Québec, Canada.

Correspondence to Jean Raymond, MD, Department of Radiology, Notre-Dame Hospital, 1560 Sherbrooke East, Suite M-8203, Montreal, Quebec, H2L 4M1, Canada. E-mail dr_jean_raymond{at}hotmail.com

Abstract

Background and Purpose— Beta radiation can prevent recanalization after embolization. Our goal was to assess the feasibility of endovascular treatment of intracranial aneurysms using coils of a predetermined activity of ³²P per centimeter.

Methods— We studied the total length of coils deployed into 357 intracranial aneurysms. Aneurysmal volumes were estimated using 3 mathematical models. We simulated that coils were implanted with 0.26 µCi/cm of ³²P, calculated resulting volumetric activities, and compared them with "effective" levels derived from experimental data and "safe" levels prescribed for the clinical use of ³²P in cystic craniopharyngiomas.

Results— Effective activities would have been reached in 92% to 98% of lesions had the coils been radioactive at the time of treatment.

Conclusion— Radioactive coil embolization of aneurysms is feasible in most patients.

Key Words: aneurysm • endovascular therapy • radiation

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