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(Stroke. 2003;34:1207.)
© 2003 American Heart Association, Inc.

Original Contributions

Elastin Polymorphism Haplotype and Intracranial Aneurysms Are Not Associated in Central Europe

Anne Hofer, MD; Marcella Hermans, MD; Nina Kubassek, MSc; Matthias Sitzer, MD; Harald Funke, MD; Florian Stögbauer, MD; Vytautas Ivaskevicius, MD; Johannes Oldenburg, MD; Johannes Burtscher, MD; Ulrich Knopp, MD; Beate Schoch, MD; Isabel Wanke, MD; Felix Hübner, MD; Wolfgang Deinsberger, MD; Bernhard Meyer, MD; Hans Boecher-Schwarz, MD; Werner Poewe, MD; Andreas Raabe, MD; Helmuth Steinmetz, MD Georg Auburger, MD

From the Department of Neurology (A.H., M.H., N.K., M.S., H.S., G.A.), Department of Neurosurgery (A.R.), and Institute of Transfusion Medicine and Immunohaematology (V.I., J.O.), Johann Wolfgang Goethe-University Frankfurt am Main; Departments of Clinical Chemistry and Laboratory Medicine (H.F.) and Neurology (F.S.), Westfalische Wilhelms-University, Munster; Departments of Neurosurgery (J.B.) and Neurology (W.P.), Leopold Franzens University Innsbruck; Department of Neurosurgery (U.K.), University of Lubeck; Departments of Neurosurgery (B.S.) and Neuroradiology (I.W.), University of Essen; Department of Neurosurgery (F.H.), University of Ulm; Department of Neurosurgery (W.D.), Justus-Liebig University, Giessen; Department of Neurosurgery (B.M.), University of Bonn; and Department of Neurosurgery (H.B-S.), Johannes Gutenberg University, Mainz, Germany.

Correspondence to Georg Auburger, MD, Dept of Neurology, JW Goethe-University Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt, Germany. E-mail auburger{at}em.uni-frankfurt.de

Background and Purpose— The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients.

Methods— We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls.

Results— We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm.

Conclusion— Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.

Key Words: elastin • genetics • intracranial aneurysm • polymorphism, single nucleotide • subarachnoid hemorrhage

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