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(Stroke. 2004;35:415.)
© 2004 American Heart Association, Inc.

Original Contributions

Thalamic Lesions in Vascular Dementia

Low Sensitivity of Fluid-Attenuated Inversion Recovery (FLAIR) Imaging

António J. Bastos Leite, MD; Elisabeth C.W. van Straaten, MD; Philip Scheltens, MD, PhD; Geert Lycklama, MD, PhD Frederik Barkhof, MD, PhD

From the Department of Radiology (A.J.B.L., G.L., F.B.), Department of Neurology (E.C.W. van S., P.S.), Image Analysis Center (E.C.W. van S., F.B.), and Alzheimer Center (P.S.), Vrije Universiteit Medical Center, Amsterdam, Netherlands; and Department of Neuroradiology, Hospital Geral de Santo António, Oporto, Portugal (A.J.B.L.).

Correspondence to Dr Frederik Barkhof, Department of Radiology, VU Medical Center, PO Box 7057, 1007 MB Amsterdam, Netherlands. E-mail f.barkhof{at}vumc.nl

Background and Purpose— The criteria of the National Institute of Neurological Disorders and Stroke (NINDS)–Association Internationale pour la Recherche et l’Enseignement en Neurosciences (AIREN) include thalamic lesions for the diagnosis of vascular dementia (VaD). Although studies concerning VaD and brain aging advocate the use of fluid-attenuated inversion recovery (FLAIR) or T2-weighted images (T2-WI) to detect ischemic lesions, none compared the sensitivity of these sequences to depict thalamic lesions.

Methods— We performed a blinded review of T2-WI and FLAIR images in 73 patients fulfilling the radiological part of the NINDS-AIREN criteria (mean age, 71 years; range, 49 to 83 years). This sample was drawn from a large multicenter trial on VaD and was expected to have a high prevalence of thalamic lesions. In a side-by-side review, including T1-weighted images as well, lesions were classified according to presumed underlying pathology.

Results— The total number of thalamic lesions was 214. Two hundred eight (97%) were detected on T2-WI, but only 117 (55%) were detected on FLAIR (²=5.1; P<0.05). Although the mean size of lesions detected on T2-WI and not on FLAIR (4.4 mm) was significantly lower than the mean size of lesions detected on both sequences (6.7 mm) (P<0.001), 5 of the 29 lesions >10 mm on T2-WI were not visible on FLAIR. FLAIR detected only 81 (51%) of the 158 probable ischemic lesions and 30 (60%) of the 50 probable microbleeds.

Conclusions— FLAIR should not be used as the only T2-weighted sequence to detect thalamic lesions in patients suspected of having VaD.

Key Words: dementia, vascular • magnetic resonance imaging • thalamus

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