This Article Full Text Full Text (PDF) All Versions of this Article: 35/5/1107    most recent 01.STR.0000124125.19773.40v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Seidel, G. Articles by Aach, T. Search for Related Content PubMed PubMed Citation Articles by Seidel, G. Articles by Aach, T. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB SULFUR HEXAFLUORIDE Related Collections Acute Cerebral Infarction Doppler ultrasound, Transcranial Doppler etc.

(Stroke. 2004;35:1107.)
© 2004 American Heart Association, Inc.

Original Contributions

Ultrasound Perfusion Imaging in Acute Middle Cerebral Artery Infarction Predicts Outcome

Günter Seidel, MD; Karsten Meyer-Wiethe, MD; Grit Berdien; Dirk Hollstein; Daniel Toth, Dipl-Phys Til Aach, Prof. Dr.-Ing.

From Department of Neurology (G.S., K.M.-W., G.B.), University Hospital Schleswig-Holstein, Campus Lübeck, Germany; and Institute for Signal Processing (D.H., D.T., T.A.), University of Lübeck, Germany.

Correspondence to Dr Günter Seidel, University Hospital Schleswig-Holstein, Campus Lübeck, Department of Neurology, Ratzeburger Allee 160 D-23538 Lübeck, Germany. E-mail seidel_g{at}neuro.mu-luebeck.de

Background and Purpose— Initial reports indicate that transcranial harmonic imaging after ultrasound contrast agent bolus injection (BHI) can detect cerebral perfusion deficits in acute ischemic stroke. We evaluated parametric images of the bolus washout kinetics.

Methods— Twenty-three patients with acute internal carotid artery infarction were investigated with perfusion harmonic imaging after SonoVue bolus injection 40 hour after the onset of symptoms. The findings were compared with those of cranial computed tomography (CCT) and clinical course 4 months after stroke.

Results— Images of pixel-wise peak intensity (PPI) and time to peak intensity could be calculated for all patients. Spearman rank correlations of r=0.772 (P<0.001) and r=0.572 (P=0.008) between area of PPI signal decrease and area of infarction in the follow-up CCT as well as outcome after 4 months were obtained, respectively.

Conclusions— In the early phase of acute ischemic stroke, BHI after SonoVue bolus injection is a useful ultrasound tool for analyzing cerebral perfusion deficits at the patient’s bedside. BHI data correlate with the definite area of infarction and outcome after 4 months.

Key Words: ultrasonography • stroke • contrast media

This article has been cited by other articles:

				E. Vicenzini, R. Delfini, F. Magri, F. Puccinelli, M. Altieri, A. Santoro, M. F. Giannoni, L. Bozzao, V. Di Piero, and G. L. Lenzi Semiquantitative Human Cerebral Perfusion Assessment With Ultrasound in Brain Space-Occupying Lesions: Preliminary Data J. Ultrasound Med., May 1, 2008; 27(5): 685 - 692. [Abstract] [Full Text] [PDF]

				J. M. Abadal, J. A. Llompart-Pou, J. Homar, J. Velasco, J. Ibanez, and J. Perez-Barcena Ultrasonographic Cerebral Perfusion in Assessment of Brain Death: A Preliminary Study J. Ultrasound Med., May 1, 2008; 27(5): 791 - 794. [Abstract] [Full Text] [PDF]

				E. Bartels and H.-J. Bittermann Transcranial Contrast Imaging of Cerebral Perfusion in Patients With Space-Occupying Intracranial Lesions J. Ultrasound Med., April 1, 2006; 25(4): 499 - 507. [Abstract] [Full Text] [PDF]

				J. Eyding, C. Krogias, S. Meves, H. Przuntek, T. Postert, G. Seidel, and K. Meyer-Wiethe Quantitative Ultrasonographic Evaluation of Cerebral Perfusion in Acute Stroke Is Possible Stroke, November 1, 2004; 35(11): 2432 - 2433. [Full Text] [PDF]