This Article Full Text Full Text (PDF) All Versions of this Article: 35/5/e109    most recent 01.STR.0000125711.94465.78v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ramee, S. R. Articles by White, C. J. Search for Related Content PubMed PubMed Citation Articles by Ramee, S. R. Articles by White, C. J. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Angioplasty Stroke Hazardous Substances DB HEPARIN Related Collections Cerebrovascular disease/stroke Acute Cerebral Infarction Acute Stroke Syndromes Thrombolysis Angioplasty and Stenting Other Stroke

(Stroke. 2004;35:e109.)
© 2004 American Heart Association, Inc.

Research Report

Catheter-Based Treatment for Patients With Acute Ischemic Stroke Ineligible for Intravenous Thrombolysis

Stephen R. Ramee, MD; Rajesh Subramanian, MBBS; Robert A. Felberg, MD; Kevin L. McKinley, MD; J. Stephen Jenkins, MD; Tyrone J. Collins, MD; Robert C. Dawson, MD Christopher J. White, MD

From Department of Cardiology (S.R.R., R.S., J.S.J., T.J.C., C.J.W.), Department of Neurology (R.A.F., K.L.M.), Division of Neuroradiology, Department of Neurosurgery (R.C.D.), Ochsner Clinic Foundation, New Orleans, La.

Correspondence to Dr Stephen R. Ramee, Section Head: Invasive Cardiology, Department of Cardiology, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121. E-mail sramee{at}ochsner.org

Background and Purpose— We present our single-center experience using catheter-based therapy for acute ischemic stroke patients who were not candidates for intravenous thrombolytic therapy.

Methods— Neurologic outcomes were assessed in patients with acute ischemic stroke, ineligible for intravenous thrombolysis, treated with an emergent catheter-based therapy.

Results— Nonparametric analysis of neurological outcomes demonstrated a benefit in National Institutes of Health Stroke Scale (NIHSS) at long-term follow-up (P=0.036). Independence in daily activities and improvement in NIHSS of 4 points were achieved in 38% and 56% of patients, respectively. Four patients (25%) died, including 2 patients (12.5%) who died from intracranial hemorrhage.

Conclusions— Catheter-based treatment offers a promising treatment strategy in patients with acute ischemic stroke ineligible for intravenous thrombolysis.

Key Words: stroke, acute • stroke management • thrombolysis

This article has been cited by other articles:

				C. Brekenfeld, G. Schroth, H. P. Mattle, D.-D. Do, L. Remonda, P. Mordasini, M. Arnold, K. Nedeltchev, N. Meier, and J. Gralla Stent Placement in Acute Cerebral Artery Occlusion: Use of a Self-Expandable Intracranial Stent for Acute Stroke Treatment Stroke, March 1, 2009; 40(3): 847 - 852. [Abstract] [Full Text] [PDF]

				E. Mahmud, J. J. Cavendish, and A. Salami Current Treatment of Peripheral Arterial Disease: Role of Percutaneous Interventional Therapies J. Am. Coll. Cardiol., August 7, 2007; 50(6): 473 - 490. [Abstract] [Full Text] [PDF]

				A. Ciccone and F. Scomazzoni Intra-Arterial Thrombolysis for Acute Ischemic Stroke Stroke, August 1, 2006; 37(8): 1962 - 1962. [Full Text] [PDF]

				R.G. Gonzalez Imaging-guided acute ischemic stroke therapy: From "time is brain" to "physiology is brain". AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 728 - 735. [Abstract] [Full Text] [PDF]

				R.M. Sugg, E.A. Noser, H.M. Shaltoni, N.R. Gonzales, M.S. Campbell, R. Weir, E.D. Cacayorin, and J.C. Grotta Intra-arterial reteplase compared to urokinase for thrombolytic recanalization in acute ischemic stroke. AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 769 - 773. [Abstract] [Full Text] [PDF]